Search for Drugs Used in Hospitals to Treat Stomatitis.
Search for Drugs Used in Hospitals to Treat Stomatitis.
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DOI：
10.3390/medicines6010019
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发表时间：
2019-01-29
期刊：
影响因子：
--
通讯作者：
Sakagami, Hiroshi
中科院分区：
文献类型：
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作者：
Hara, Yaeko;Shiratuchi, Hiroshi;Sakagami, Hiroshi
口腔炎是口腔粘膜的一种炎症性疾病，常伴有疼痛。通常以口疮性口炎为代表，通常使用类固醇软膏进行治疗。然而，对于难治性或复发性口腔炎，使用传统草药具有良好的治疗效果。化疗，尤其是头颈部化疗，诱发口腔炎的频率较高，直接影响患者的生活质量和治疗进度。然而，口腔炎的有效治疗方法尚未建立。本文介绍了日本大学汉方药物治疗口腔炎患者的临床报告，并对传统药物治疗口腔炎的文献进行了综述。在 18 种汉方药物中，Hangeshhinto 因其突出的抗炎活性而成为治疗口腔炎最受欢迎的药物。令人意外的是，中国医院却没有Hangeshashinto治疗口腔炎的临床数据。与儿童相比，汉方药物主要针对老年人。补充富含木质素-碳水化合物复合物的碱性植物提取物可以进一步扩展汉方药物对病毒性疾病的适用性。
Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Chemotherapy, especially in the head and neck region, induces stomatitis at higher frequency, which directly affects the patient's quality of life and treatment schedule. However, effective treatment for stomatitis has yet to be established. This article presents the clinical report of Kampo medicines on the stomatitis patients in the Nihon university, and then reviews the literature of traditional medicines for the treatment of stomatitis. Among eighteen Kampo medicines, Hangeshashinto has been the most popular for the treatment of stomatitis, due to its prominent anti-inflammatory activity. It was unexpected that clinical data of Hangeshashinto on stomatitis from Chinese hospital are not available. Kampo medicines have been most exclusively administered to elder person, as compared to pediatric population. Supplementation of alkaline plant extracts rich in lignin-carbohydrate complex may further extend the applicability of Kampo medicines to viral diseases.