New insights into the function and regulation of endothelial cell apoptosis
New insights into the function and regulation of endothelial cell apoptosis
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DOI：
10.1023/b:agen.0000021390.09275.bc
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发表时间：
2003-01-01
期刊：
影响因子：
9.8
通讯作者：
Print, Cristin
中科院分区：
文献类型：
--
作者：
Duval, Helene;Harris, Mike;Print, Cristin
塑造血管以满足其所供应的组织不断变化的需求对于生命至关重要。许多研究人员认为内皮细胞凋亡在此过程中发挥着重要作用。边缘重塑血管内内皮细胞凋亡的检测、内皮细胞凋亡调节因子已失活的小鼠显着的血管表型以及体外血管生成对内皮细胞凋亡的明显依赖性都支持了这一信念。然而，当仔细检查时，支持或反对内皮细胞凋亡在血管生物学中发挥重要作用的证据很大程度上是间接的，而且远非明确。在这篇综述中，我们将讨论内皮细胞凋亡的特殊过程。然后，我们将检查其复杂的调节，并权衡其在哺乳动物血管生物学中发挥重要作用的体外和体内证据。
The sculpting of blood vessels to meet the changing requirements of the tissues they supply is essential for life. Many researchers believe that endothelial cell apoptosis plays an important role in this process. This belief is bolstered by the detection of endothelial apoptosis within remodeling vessels in rim, the dramatic vascular phenotypes of mice in which regulators of endothelial apoptosis have been inactivated and the apparent dependence of angiogenesis on endothelial apoptosis in vitro. However, when examined carefully, the evidence for or against endothelial cell apoptosis playing an important role in vascular biology is largely indirect and is far from clear-cut. In this review, we will discuss the idiosyncratic process of endothelial cell apoptosis. We will then examine its complex regulation and weigh the in vitro and in vivo evidence that it plays a significant role in mammalian vascular biology.