PYROGENS SPECIFICALLY DISRUPT THE ACQUISITION OF A TASK INVOLVING COGNITIVE PROCESSING IN THE RAT
PYROGENS SPECIFICALLY DISRUPT THE ACQUISITION OF A TASK INVOLVING COGNITIVE PROCESSING IN THE RAT
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DOI：
10.1006/brbi.1995.1013
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发表时间：
1995-06-01
影响因子：
15.1
通讯作者：
GOODALL, G
中科院分区：
文献类型：
--
作者：
AUBERT, A;VEGA, C;GOODALL, G
除了与免疫激活相对应的体温变化和其他代谢和生理反应外，热原还可诱导严重的行为变化，统称为疾病行为。病态行为的一个特征是认知功能低下，有时在临床环境中报道，但很少暴露于实验分析。本系列的5项实验旨在证明大鼠存在特定的认知缺陷，与热原注射的任何混淆性能影响无关。所使用的行为任务称为自动成形，包括向饥饿的Wistar大鼠提供预测食物递送的刺激（引入可伸缩杠杆）。对照组大鼠很快学会了按下杠杆，尽管这种反应并不影响食物输送的可能性。当热原（250 μ g/kg脂多糖，4 μ g/大鼠白细胞介素-1 β，或300 mg/大鼠酵母）注射到大鼠在收购这个任务，他们严重破坏收购，而热原是活跃的。然而，当性能稳定时，当稍后注射时，相同的处理对性能没有影响。II认为，这些结果证明了热源对获得该任务所需的认知过程的特定的、与表现无关的影响。结果进行了讨论，在这些影响和热原在大脑中诱导的细胞因子之间的关系，并在可能受到影响的认知过程的确切性质。(C)出版社：Academic Press
In addition to changes in body temperature and other metabolic and physiological responses corresponding to immune activation, pyrogens can induce profound behavioral changes referred to collectively as sickness behavior. One feature of sickness behavior, sometimes reported in clinical settings, but rarely exposed to experimental analysis, is depressed cognitive functioning. The present series of five experiments sought to demonstrate the existence of specific cognitive deficits in rats, independently of any confounding performance effects of pyrogen injections. The behavioral task used, called autoshaping, consisted of presenting hungry Wistar rats with a stimulus (introduction of a retractable lever) that predicted food delivery. Control rats quickly learned to press the lever, although this response does not influence the probability of food delivery. When pyrogens (250 mu/kg lipopolysaccharide, 4 mu g/rat interleukin-1 beta, or 300 mg/rat yeast) were injected to rats during acquisition of this task, they severely disrupted acquisition while the pyrogen was active. The same treatments were, however, without effect on performance when injected later, when performance had stabilized. II is argued that these results demonstrate specific, performance-independent effects of pyrogens on the cognitive processes needed for the acquisition of this task. The results are discussed in terms of the relationship between these effects and the cytokines induced in the brain by pyrogens, and in terms of the exact nature of the cognitive process likely to be affected. (C) 1995 Academic Press,Inc.