Similar liver function abnormalities occur in patients receiving glucose-based and lipid-based parenteral nutrition.
Similar liver function abnormalities occur in patients receiving glucose-based and lipid-based parenteral nutrition.
复制标题
接受基于葡萄糖和脂质的肠外营养的患者也会出现类似的肝功能异常。
DOI：
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发表时间：
1983
影响因子：
9.8
通讯作者：
H. Silberman
中科院分区：
文献类型：
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作者：
W. Wagner;A. Lowry;H. Silberman
肝功能障碍的生化和组织病理学证据与基于葡萄糖的全肠外营养（TPN）的使用有关。本研究对40例患者全肠外营养过程中的肝脏指标SGOT、SGPT、碱性磷酸酶和胆红素进行了回顾性分析。 15 名患者接受了基于葡萄糖的系统，25 名患者接受了基于脂质的系统。在接受任一系统的大多数患者中发现至少一个测量参数出现短暂升高。这些数据证实了之前关于接受基于葡萄糖的全肠外营养的患者肝功能测试异常的报告。然而，与之前的研究结果相反，在使用脂质作为主要热量来源的营养支持系统的管理过程中也观察到了这些紊乱。
Biochemical and histopathological evidence of hepatic dysfunction has been associated with the use of glucose-based total parenteral nutrition (TPN). In the present study liver indices, SGOT, SGPT, alkaline phosphatase, and bilirubin, were analyzed retrospectively during the course of total parenteral nutrition in 40 patients; 15 patients received a glucose-based system and 25 received a lipid-based system. Transient elevations in at least one of the measured parameters were found in a majority of patients receiving either system. These data confirm previous reports of liver function test abnormalities in patients receiving glucose-based total parentual nutrition. However, in contrast to results from prior studies, these derangements also were observed during the administration of a nutritional support system using lipids as the primary source of calories.