An analysis of synapsin II, a neuronal phosphoprotein, in postmortem brain tissue from alcoholic and neuropsychiatrically ill adults and medically ill children and young adults.
An analysis of synapsin II, a neuronal phosphoprotein, in postmortem brain tissue from alcoholic and neuropsychiatrically ill adults and medically ill children and young adults.
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DOI：
10.1001/archpsyc.1990.01810240069011
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发表时间：
1990-12
影响因子：
--
通讯作者：
J. Grebb;P. Greengard
中科院分区：
文献类型：
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作者：
J. Grebb;P. Greengard
突触蛋白II（以前称为蛋白III）是一种突触囊泡相关的神经元磷蛋白，可能参与调节神经递质的释放。突触蛋白II研究了132个不同的神经精神和医学诊断的人死后的大脑样本。突触蛋白II的分子量变体存在于73%的酒精中毒个体的样本中，但仅存在于31%的非患病个体的样本中，从而证实了我们先前关于突触蛋白II变体与酒精中毒之间的关联的两个报告。突触蛋白II变体的存在与年龄或营养状态无关。56%的精神分裂症患者样本和41%的亨廷顿病患者样本中也存在突触蛋白II变异体。突触蛋白II变体存在于儿童和年轻人的样本中，这与突触蛋白II变体可能反映遗传特征的可能性一致。在18个酒精中毒、衰老或维生素B缺乏的啮齿动物模型中没有发现突触蛋白II变体，这表明突触蛋白II变体可能是人类独有的特征。
Synapsin II (formerly known as protein III) is a synaptic vesicle-associated neuronal phosphoprotein that may be involved in the regulation of neurotransmitter release. Synapsin II was studied in postmortem brain samples from 132 individuals with various neuropsychiatric and medical diagnoses. Molecular weight variants of synapsin II were present in 73% of samples from alcoholic individuals but in only 31% of samples from non-diseased individuals, thus confirming our two previous reports of an association between synapsin II variants and alcoholism. The presence of synapsin II variants was not correlated with age or nutritional state. Synapsin II variants were also present in 56% of samples from individuals with schizophrenia and 41% of samples from individuals with Huntington's disease. Synapsin II variants were present in samples from children and young adults, consistent with the possibility that synapsin II variants may reflect a genetically inherited trait. Synapsin II variants were not found in any of 18 rodent models of alcoholism, aging, or vitamin B deficiency, suggesting that synapsin II variants may be a uniquely human trait.