The molecular mechanisms of diapause and diapause-like reversible arrest.
The molecular mechanisms of diapause and diapause-like reversible arrest.
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DOI：
10.1042/bst20221431
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发表时间：
2023-10-31
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
滞育是许多生物克服环境逆境的一种保护机制。滞育延长了寿命和生育能力，提高了物种的繁殖成功率和存活率。虽然滞育状态已经被了解并用于商业目的，例如在丝绸工业中，详细的分子和细胞生物学研究是一个令人兴奋的前沿。了解滞育样的保护机制将揭示引导生物体通过不利条件的途径。一个希望是，对支持滞育的机制的理解可以用来延长人类以及受气候变化威胁的物种的寿命和/或健康寿命。此外，最近的研究结果表明，癌细胞在治疗后持续存在，模仿滞育样状态，这意味着这些程序可能促进癌细胞从化疗中存活并导致复发。在这里，我们回顾了多种生物中滞育程序的分子机制，并讨论了肿瘤持续细胞中支持滞育样状态的途径。
Diapause is a protective mechanism that many organisms deploy to overcome environmental adversities. Diapause extends lifespan and fertility to enhance the reproductive success and survival of the species. Although diapause states have been known and employed for commercial purposes, for example in the silk industry, detailed molecular and cell biological studies are an exciting frontier. Understanding diapause-like protective mechanisms will shed light on pathways that steer organisms through adverse conditions. One hope is that an understanding of the mechanisms that support diapause might be leveraged to extend the lifespan and/or health span of humans as well as species threatened by climate change. In addition, recent findings suggest that cancer cells that persist after treatment mimic diapause-like states, implying that these programs may facilitate cancer cell survival from chemotherapy and cause relapse. Here, we review the molecular mechanisms underlying diapause programs in a variety of organisms, and we discuss pathways supporting diapause-like states in tumor persister cells.
影响因子：
4.6
作者：
Yokoyama T;Saito S;Shimoda M;Kobayashi M;Takasu Y;Sezutsu H;Kato Y;Tominaga M;Mizoguchi A;Shiomi K
通讯作者：
Shiomi K