Dosimetric characterization of the GammaClip™ 169Yb low dose rate permanent implant brachytherapy source for the treatment of nonsmall cell lung cancer postwedge resection.
Dosimetric characterization of the GammaClip™ 169Yb low dose rate permanent implant brachytherapy source for the treatment of nonsmall cell lung cancer postwedge resection.
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用于治疗楔形切除术后非小细胞肺癌的 GammaClip™ 169Yb 低剂量率永久植入近距离放射治疗源的剂量测定特征。
DOI：
10.1118/1.4812675
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发表时间：
2013
期刊：
影响因子：
3.8
通讯作者：
Medich,DavidC
中科院分区：
文献类型：
--
作者：
Currier,Blake;Munro3rd,JohnJ;Medich,DavidC
目的：Source Production & Equipment Co.（New Orleans，LA）开发了一种新型169 Yb低剂量率永久性植入近距离放射治疗源GammaClip™，其设计类似于外科缝合钉，同时提供治疗辐射。在本报告中，根据Perez‐Calatayudet等人的“平均能量高于50 keV的光子发射近距离放射治疗源的剂量计算：AAPM和ESTRO报告”对近距离放射治疗源进行了表征。[Med.方法：在水和空气中使用Monte Carlo N-Particle 5，版本1.6进行Monte Carlo计算，根据TG-43 U1建议和先前审查的169 Yb能量截止水平，过滤空气中的光子光谱以去除低于10 keV的光子能量[D. C. Medich，M. A.尝试，和J.M. Munro，“镱-169高剂量率近距离放射治疗源的Monte Carlo表征及统计不确定性分析”，《医学物理》33，163-172（2006）] 10.1118/1.2147767。计算了TG-43 U1剂量测定数据，包括SK、Λ、gL（r）、F（r，θ）、μ an（r）和及其统计不确定度。由于放射源不是轴对称的，因此我们进行了一组额外的计算来评估由此产生的轴向各向异性。结果：近距离放射治疗源的剂量率常数计算为（1.22 ± 0.03）cGy h−1U−1。水剂量计算的不确定性确定为2.5%，主要是横截面的不确定性。各向异性常数计算为0.960 ± 0.011，通过使用比例为tor−2的加权因子对1和10 cm之间的各向异性因子进行积分获得。在0.5 - 12 cm距离处计算径向剂量函数，在5.15 ± 0.03 cm处的最大值为1.20。径向剂量值拟合为五阶多项式和双指数回归。结论：169 Yb具有较高的光子能量、较短的半衰期和较高的初始剂量率，是治疗非小细胞肺癌的一种有意义的替代125 I的方法。
Purpose:A novel169Yb low dose rate permanent implant brachytherapy source, the GammaClip™, was developed by Source Production & Equipment Co. (New Orleans, LA) which is designed similar to a surgical staple while delivering therapeutic radiation. In this report, the brachytherapy source was characterized in terms of “Dose calculation for photon‐emitting brachytherapy sources with average energy higher than 50 keV: Report of the AAPM and ESTRO” by Perez‐Calatayudet al.[Med. Phys. 39, – (2012)] 10.1118/1.3703892 using the updated AAPM Task Group Report No. 43 formalism.Methods:Monte Carlo calculations were performed using Monte Carlo N‐Particle 5, version 1.6 in water and air, the in‐air photon spectrum filtered to remove photon energies below 10 keV in accordance with TG‐43U1 recommendations and previously reviewed169Yb energy cutoff levels [D. C. Medich, M. A. Tries, and J. M. Munro, “Monte Carlo characterization of an Ytterbium‐169 high dose rate brachytherapy source with analysis of statistical uncertainty,” Med. Phys. 33, 163–172 (2006)] 10.1118/1.2147767. TG‐43U1 dosimetric data, includingSK, , Λ,gL(r),F(r,θ),ϕan(r), and were calculated along with their statistical uncertainties. Since the source is not axially symmetric, an additional set of calculations were performed to assess the resulting axial anisotropy.Results:The brachytherapy source's dose rate constant was calculated to be (1.22 ± 0.03) cGy h−1U−1. The uncertainty in the dose to water calculations, , was determined to be 2.5%, dominated by the uncertainties in the cross sections. The anisotropy constant, , was calculated to be 0.960 ± 0.011 and was obtained by integrating the anisotropy factor between 1 and 10 cm using a weighting factor proportional tor−2. The radial dose function was calculated at distances between 0.5 and 12 cm, with a maximum value of 1.20 at 5.15 ± 0.03 cm. Radial dose values were fit to a fifth order polynomial and dual exponential regression. Since the source is not axially symmetric, angular Monte Carlo calculations were performed at 1 cm which determined that the maximum azimuthal anisotropy was less than 8%.Conclusions:With a higher photon energy, shorter half‐life and higher initial dose rate169Yb is an interesting alternative to125I for the treatment of nonsmall cell lung cancer.
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DOI：
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DOI：
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