Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate
Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate
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DOI：
10.1039/c0cc04733c
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Mulchandani, Ashok
中科院分区：
文献类型：
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作者：
Das, Basanta K.;Tlili, Chaker;Mulchandani, Ashok
在这里，我们报告了基于单壁碳纳米管(SWNTs)的化学电阻适配传感器，用于使用置换格式对弱或不带电荷的分子进行高灵敏度和选择性的检测。作为概念验证，我们展示了通过置换与SWNTs上共价连接的小捕获寡核苷酸杂交的ssDNA反ATP适配子来检测ATP，这种小分子具有比GTP更高的皮摩尔灵敏度和选择性。
Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.