Genebank genomics highlights the diversity of a global barley collection
Genebank genomics highlights the diversity of a global barley collection
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DOI：
10.1038/s41588-018-0266-x
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发表时间：
2019-02-01
期刊：
影响因子：
30.8
通讯作者：
Stein, Nils
中科院分区：
文献类型：
--
作者：
Milner, Sara G.;Jost, Matthias;Stein, Nils
基因库拥有所有主要粮食作物的栽培品种、地方品种和作物野生近缘种的全面集合，但其详细特征迄今仅限于稀疏的核心集。全基因组基因分型测序数据的分析，几乎所有的大麦加入德国异位基因库提供了深入了解全球人口结构的驯化大麦，并指出冗余和覆盖面的差距，在世界上主要的基因库之一。我们的大样本量和密集的标记数据为全基因组关联扫描提供了强大的力量。我们检测已知的和新的基因座的形态特征区分大麦genepools，找到证据的收敛选择无倒钩芒在大麦和水稻，并表明，一个主效抗性基因座赋予抗bymovirus感染已受到传统农民的青睐。这项研究概述了基因组学辅助基因库管理和利用种质资源的自然变异，人类选择在作物进化过程中的未来方向。
Genebanks hold comprehensive collections of cultivars, landraces and crop wild relatives of all major food crops, but their detailed characterization has so far been limited to sparse core sets. The analysis of genome-wide genotyping-by-sequencing data for almost all barley accessions of the German ex situ genebank provides insights into the global population structure of domesticated barley and points out redundancies and coverage gaps in one of the world's major genebanks. Our large sample size and dense marker data afford great power for genome-wide association scans. We detect known and novel loci underlying morphological traits differentiating barley genepools, find evidence for convergent selection for barbless awns in barley and rice and show that a major-effect resistance locus conferring resistance to bymovirus infection has been favored by traditional farmers. This study outlines future directions for genomics-assisted genebank management and the utilization of germplasm collections for linking natural variation to human selection during crop evolution.