FERTILITY OF FEMALE MICE FED COUMESTROL AND DIETHYLSTILBESTROL
FERTILITY OF FEMALE MICE FED COUMESTROL AND DIETHYLSTILBESTROL
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DOI：
10.1080/03601238409372442
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发表时间：
1984-01-01
影响因子：
2
通讯作者：
KINCAID, RL
中科院分区：
文献类型：
--
作者：
ELIAS, EA;KINCAID, RL
Coumestrol, a compound produced by various legumes which exerts estrogen-like activity in animals, and diethylstilbestrol (DES) were studied as chemical agents for controlling reproduction in mice. Female mice were fed control diets or diets containing 100 ppm coumestrol for 8 days. Female mice were exposed to males and reproductive tracts examined 14 days later. Litter size was not affected by 100 ppm dietary coumestrol but feed consumption was reduced 17%. Similar trials were conducted with mice fed 1 ppm DES. Vaginal plugs were present in 50% of the females fed 1 ppm DES, but no fetal pups were present. Feed intake was reduced 37% by the DES. Levels of 0, 0.1, 0.25, 0.50, 0.75 and 1.0 ppm DES were compared in 2 strains of mice, Swiss and ICR. Reproduction in both strains was totally inhibited by all DES treatments. The use of DES to control rodent populations warrants further investigation.
