Functional magnetic resonance imaging study of the brain in patients with amyotrophic lateral sclerosis.
Functional magnetic resonance imaging study of the brain in patients with amyotrophic lateral sclerosis.
复制标题
肌萎缩侧索硬化症患者大脑的功能磁共振成像研究。
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Lin Ma
中科院分区：
文献类型：
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作者：
Jing Han;Lin Ma
目标
使用血氧水平依赖（BOLD）功能磁共振成像（fMRI）方法研究肌萎缩侧索硬化症（ALS）患者在执行连续手指敲击运动时大脑的激活变化。
方法
纳入了 15 名确诊或疑似 ALS 患者以及 15 名年龄和性别匹配的正常对照。 MRI 在具有标准头线圈的 3. 0 Tesla 扫描仪上进行。使用梯度回波单次回波平面成像（EPI）序列获取功能图像。所有患者和正常受试者在块设计运动任务期间以 1-2 Hz 的频率执行连续的手指敲击运动。使用三维快速破坏梯度回波 (3D-FSPGR) 序列获取结构 MRI。通过统计参数映射（SPM）分析功能磁共振成像数据。
结果
在执行相同的运动任务时，ALS 患者和正常对照者的双侧初级感觉运动皮层 (PSM)、双侧运动前区 (PA)、双侧辅助运动区 (SMA)、双侧顶叶区 (PAR)、对侧下外侧运动前区 (ILPA) 和同侧小脑均表现出激活。 ALS患者双侧PSM、双侧PA、双侧SMA和同侧小脑的激活面积均显着大于正常对照组（P < 0.05）。仅在 ALS 患者中检测到额外的激活区域，包括同侧 ILPA、双侧内囊后肢和对侧小脑。
结论
ALS 患者和正常受试者在执行相同的运动任务时会激活类似的激活区域。 ALS 患者激活区域的增加可能代表神经重组，而 ALS 患者额外的激活区域可能表明功能代偿。
OBJECTIVE
To study the activation changes of the brain in patients with amyotrophic lateral sclerosis (ALS) while executing sequential finger tapping movement using the method of blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI).
METHODS
Fifteen patients with definite or probable ALS and fifteen age and gender matched normal controls were enrolled. MRI was performed on a 3. 0 Tesla scanner with standard headcoil. The functional images were acquired using a gradient echo single shot echo planar imaging (EPI) sequence. All patients and normal subjects executed sequential finger tapping movement at the frequency of 1-2 Hz during a block-design motor task. Structural MRI was acquired using a three-dimensional fast spoiled gradient echo (3D-FSPGR) sequence. The fMRI data were analyzed by statistical parametric mapping (SPM).
RESULTS
Bilateral primary sensorimotor cortex (PSM), bilateral premotor area (PA), bilateral supplementary motor area (SMA), bilateral parietal region (PAR), contralateral inferior lateral premotor area (ILPA), and ipsilateral cerebellum showed activation in both ALS patients and normal controls when executing the same motor task. The activation areas in bilateral PSM, bilateral PA, bilateral SMA, and ipsilateral cerebellum were significantly larger in ALS patients than those in normal controls (P < 0.05). Extra activation areas including ipsilateral ILPA, bilateral posterior limb of internal capsule, and contralateral cerebellum were only detected in ALS patients.
CONCLUSIONS
Similar activation areas are activated in ALS patients and normal subjects while executing the same motor task. The increased activation areas in ALS patients may represent neural reorganization, while the extra activation areas in ALS patients may indicate functional compensation.