Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization
Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: Disruption by cocaine sensitization
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DOI：
10.1016/j.neuron.2005.06.017
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发表时间：
2005-07-21
期刊：
影响因子：
16.2
通讯作者：
Grace, AA
中科院分区：
文献类型：
--
作者：
Goto, Y;Grace, AA
前额叶皮层和海马体向伏隔核表现出收敛的投射，并通过间接途径具有功能性的相互联系。因此，这些结构之间的信息处理很可能是双向的。使用诱发电位测量，我们检查了这些输入对伏隔核内突触可塑性的相互作用。我们的研究结果表明，前额叶皮层和边缘结构之间信息流动的方向决定了这些输入在伏隔脑内表现出的突触可塑性。此外，海马和前额叶输入的突触可塑性选择性地分别涉及多巴胺D1和D2的激活或失活。在空间迷宫任务中，反复使用可卡因破坏了海马和前额叶皮层输入和目标导向行为的突触可塑性。因此，大脑边缘-前额叶皮层突触可塑性的相互作用及其在伏隔体内的功能障碍可能是在服用精神兴奋剂后观察到的个体复杂信息加工缺陷的基础。
The prefrontal cortex and the hippocampus exhibit converging projections to the nucleus accumbens and have functional reciprocal connections via indirect pathways. As a result, information processing between these structures is likely to be bidirectional. Using evoked potential measures, we examined the interactions of these inputs on synaptic plasticity within the accumbens. Our results show that the direction of information flow between the prefrontal cortex and limbic structures determines the synaptic plasticity that these inputs exhibit within the accumbens. Moreover, this synaptic plasticity at hippocampal and prefrontal inputs selectively involves dopamine D1 and D2 activation or inactivation, respectively. Repeated cocaine administration disrupted this synaptic plasticity at hippocampal and prefrontal cortical inputs and goal-directed behavior in the spatial maze task. Thus, interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration.