Immunohistochemical examination of neural cell adhesion molecule (NCAM), tenascin and fibronectin on the development of cartilaginous tissue in canine mammary mixed tumors.
Immunohistochemical examination of neural cell adhesion molecule (NCAM), tenascin and fibronectin on the development of cartilaginous tissue in canine mammary mixed tumors.
复制标题
神经细胞粘附分子（NCAM）、生腱蛋白和纤连蛋白对犬乳腺混合肿瘤软骨组织发育的免疫组织化学检查。
DOI：
10.1292/jvms.56.809
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
K. Uehara
中科院分区：
文献类型：
--
作者：
K. Arai;M. Naoi;K. Uehara
应用免疫组织化学方法检测了犬乳腺混合瘤软骨样组织形成过程中神经细胞粘附分子（NCAM）、腱生蛋白和纤维连接蛋白的表达。连续切片显示，增殖的肌上皮细胞同时表达这些粘附分子，没有软骨样组织和软骨特异性II型胶原蛋白的表达被观察到。随着软骨组织的形成，成软骨细胞样细胞中这些粘附分子的阳性信号减少，软骨组织透明化，成熟的软骨细胞样细胞不再表达这些细胞粘附分子。因此，NCAM、腱生蛋白和纤维连接蛋白可能在犬乳腺混合瘤中肌上皮细胞的增殖和软骨组织的发育中起重要作用。
The expression of neural cell adhesion molecule (NCAM), tenascin and fibronectin during cartilage-like tissue formation in canine mammary mixed tumor was immunohistochemically examined. Mirror-image serial sections revealed that proliferating myoepithelial cells simultaneously expressed these adhesion molecules where no cartilage-like tissue and no expression of cartilage-specific type II collagen were observed. With the formation of cartilaginous tissue, positive signals of these adhesion molecules decreased in chondroblast-like cells, the cartilaginous tissue was hyalinized and mature chondrocyte-like cells no longer expressed these cell adhesion molecules. NCAM, tenascin and fibronectin, therefore, may play crucial roles on the proliferation of myoepithelial cells and the subsequent development of cartilaginous tissue in canine mammary mixed tumor.