The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1
The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1
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DOI：
10.1101/gad.10.14.1783
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发表时间：
1996-07-15
影响因子：
10.5
通讯作者：
Ueda, R
中科院分区：
文献类型：
--
作者：
Takahisa, M;Togashi, S;Ueda, R
在果蝇感觉器官的发育过程中，前膜基因和抑制基因之间的活动平衡决定了前膜细胞簇是神经发育的一个有能力的细胞群。在这项研究中，我们报道了编码细胞-细胞连接相关蛋白的tamou （tam）基因的分离和分析，该基因与哺乳动物ZO-1同源，是膜相关鸟苷酸激酶同源家族的成员。tam突变减少了抑制基因extramacrochaetae的转录，并导致前膜簇的扩大，其中出现了多余的前体细胞，从而导致果蝇的额外机械感觉器官。这些结果表明，膜相关的Tam蛋白参与了激活emc表达的信号通路。
In Drosophila sensory organ development, the balance of activities between proneural genes and repressor genes defines a proneural cluster as a population of competent cells for neural development. In this study, we report the isolation and analysis of the tamou (tam) gene that encodes a cell-cell junction-associated protein, which is homologous to mammalian ZO-1, a member of the membrane-associated guanylate kinase homolog family. The tam mutation reduces the transcription of a repressor gene, extramacrochaetae, and causes enlargement of a proneural cluster where supernumerary precursor cells emerge, resulting in extra mechanosensory organs in the fly. These results suggest that the membrane-associated Tam protein is involved in the signaling pathway that activates emc expression.