Origins of neural crest cell diversity.
Origins of neural crest cell diversity.
复制标题
神经嵴细胞多样性的起源。
DOI：
10.1006/dbio.1993.1217
复制
发表时间：
1993
影响因子：
2.7
通讯作者：
Bronner-Fraser,M
中科院分区：
文献类型：
--
作者：
Selleck,MA;Scherson,TY;Bronner-Fraser,M
神经嵴是一群迁移细胞，起源于外胚层，侵入胚胎内的许多部位并分化成各种不同的细胞类型。色素细胞、周围神经系统的大多数细胞、肾上腺髓质细胞和一些颅软骨都来源于神经嵴。尽管关于它们的迁移途径和大量衍生物的知识丰富，但对神经嵴细胞的形成或它们的位置识别的获得知之甚少。本文综述了神经嵴细胞的起源和神经嵴细胞命运的差异产生的外胚层沿着吻尾轴。此外，我们认为时间限制的作用，在前迁移神经嵴细胞的发育潜力。虽然多能干细胞存在的证据是强有力的，一些实验也表明，可能有异质性之间的神经嵴细胞的前体，也许是由于起源的差异，这可能解释发生在神经嵴发育早期的承诺事件。
The neural crest is a population of migratory cells, arising from the ectoderm, that invades many sites within the embryo and differentiate into a variety of diverse cell types. Pigment cells, most cells of the peripheral nervous system, adrenal medullary cells, and some cranial cartilage are derived from the neural crest. Despite a wealth of knowledge concerning their pathways of migration and vast array of derivatives, little is known about the formation of neural crest cells or their acquisition of positional identity. This review focuses on the origin of neural crest cells from the ectoderm and the generation of differences in neural crest cell fates along the rostrocaudal axis. In addition, we consider the role of temporal restriction in the developmental potential of premigratory neural crest cells. While evidence for the existence of multipotent stem cells is strong, some experiments also suggest that there may be heterogeneity among neural crest cell precursors, perhaps due to differences in origin, that might explain commitment events occurring early in neural crest development.