Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe
Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe
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DOI：
10.1016/j.bone.2019.05.012
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发表时间：
2019-08-01
期刊：
影响因子：
4.1
通讯作者：
Ferrand, Rashida A.
中科院分区：
文献类型：
--
作者：
Gregson, Celia L.;Hartley, April;Ferrand, Rashida A.
背景：围产期获得的艾滋病毒感染通常会导致儿童发育迟缓；这如何影响骨骼和肌肉发育尚不清楚。我们调查了艾滋病毒感染者 (CWH) 和未感染儿童之间骨骼和肌肉质量以及肌肉功能的差异。背景：对接受抗逆转录病毒治疗 (ART) 超过 6 个月的 CWH（6-16 岁）和在津巴布韦初级卫生诊所检测 HIV 阴性的年龄相仿的儿童进行横断面研究。方法：通过双能 X 射线吸收测定法 (DXA)，我们计算了根据身高调整的瘦体重 (TBLH-BMCLBM) 的全身少头 (TBLH) 骨矿物质含量 (BMC) Z 分数，结果：97 名 CWH 比 77 名未感染者年龄更大（平均年龄 12.7 岁 vs. 10.0 岁）且更高（平均身高 142 厘米 vs. 134 厘米）。然而，发育迟缓（年龄别身高 Z 分数
Background: Perinatally-acquired HIV infection commonly causes stunting in children; how this affects bone and muscle development is unclear. We investigated differences in bone and muscle mass and muscle function between children with HIV (CWH) and uninfected children. Setting: Cross-sectional study of CWH (6-16 years) receiving antiretroviral therapy (ART) for > 6 months and similar aged children testing HIV-negative at primary health clinics in Zimbabwe.Methods: From Dual-energy X-ray Absorptiometry (DXA) we calculated total-body less-head (TBLH) Bone Mineral Content (BMC) for lean mass adjusted-for-height (TBLH-BMCLBM) Z-scores, and lumbar spine (LS) Bone Mineral Apparent Density (BMAD) Z-scores.Results: The 97 CWH were older (mean age 12.7 vs. 10.0 years) and taller (mean height 142 cm vs. 134 cm) than 77 uninfected. However, stunting (height-for-age Z-score