The Rush Memory and Aging Project: Study design and baseline characteristics of the study cohort
The Rush Memory and Aging Project: Study design and baseline characteristics of the study cohort
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DOI：
10.1159/000087446
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发表时间：
2005-01-01
影响因子：
5.7
通讯作者：
Wilson, RS
中科院分区：
文献类型：
--
作者：
Bennett, DA;Schneider, JA;Wilson, RS
快速记忆和衰老项目的长期目标是确定将遗传和环境风险因素与阿尔茨海默病(AD)发展联系起来的死后指标。总体研究设计包括对没有已知痴呆症的老年人的AD风险因素进行详细评估，这些老年人同意在死亡时进行年度临床评估和器官捐赠。与对特殊人群进行的其他临床病理学研究不同，快速记忆和老龄化项目招募了一组除了性别、种族和民族外，在教育程度方面具有更大多样性的队列。从1997年9月到2005年4月，来自芝加哥大都会地区30多个住宅设施的1000多名没有已知痴呆症的老年人同意参加。她们的平均年龄为81岁，约三分之一的人受过12年或更少的教育，三分之一是男性，约10%的人是种族或少数民族成员。超过950人已经完成了他们的基线临床评估。版权所有(C)2005 S.Karger AG，巴塞尔。
The long-term objective of the Rush Memory and Aging Project is to identify the postmortem indices linking genetic and environmental risk factors to the development of Alzheimer's disease ( AD). The overall study design involves a detailed assessment of risk factors for AD in older persons without known dementia who agree to annual clinical evaluation and organ donation at the time of death. In contrast to other clinical-pathologic studies which are conducted on special populations, the Rush Memory and Aging Project enrolled a cohort with much greater diversity in terms of educational attainment, in addition to gender, race, and ethnicity. From September of 1997 through April of 2005, more than 1,000 older persons without known dementia from more than 30 residential facilities across the Chicago metropolitan area agreed to participate. Their mean age was 81 years, about a third had 12 or fewer years of education, a third were men, and about 10% were members of a racial or ethnic minority group. More than 950 already have completed their baseline clinical evaluation. Copyright (C) 2005 S. Karger AG, Basel.