Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway.
Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway.
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DOI：
10.1038/ijosup.2015.4
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发表时间：
2015-08-01
期刊：
影响因子：
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通讯作者：
Kajimura, S
中科院分区：
文献类型：
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作者：
Kajimura, S
肥胖是由慢性能量失衡（能量摄入超过能量消耗）引起的。由于棕色脂肪组织 (BAT) 耗散能量并产生热量，因此通过 BAT 产热增加能量消耗可能构成治疗肥胖和肥胖相关疾病的新型治疗干预措施。过去几年的研究已经确定了棕色和米色脂肪细胞生物发生的关键调节分子，包括显性转录辅调节因子 PRDM16（PR 结构域包含 16 个）及其辅助因子，可通过遗传方法改造功能性 BAT。为了实现通过药理学方法促进 BAT 生热作用的目标，下一步需要更好地了解棕色和米色脂肪细胞发育的酶成分和信号通路。这篇综述涵盖了该主题的最新进展，特别强调了 PRDM16 转录途径。
Obesity develops from a chronic energy imbalance in which energy intake exceeds energy expenditure. As brown adipose tissue (BAT) dissipates energy and produces heat, increasing energy expenditure via BAT thermogenesis may constitute a novel therapeutic intervention for the treatment of obesity and obesity-related diseases. Studies over the past few years have identified key regulatory molecules of brown and beige adipocyte biogenesis, including a dominant transcriptional co-regulator PRDM16 (PR domain containing 16) and its co-factors, which allows for engineering functional BAT by genetic approaches. A next step toward the goal of promoting BAT thermogenesis by pharmacological approaches necessitates a better understanding of the enzymatic components and signaling pathways for brown and beige adipocyte development. This review covers recent advances regarding this topic, with a special emphasis on the PRDM16 transcriptional pathway.