Flurazepam-induced sleep apnea syndrome in a patient with insomnia and mild sleep-related respiratory changes.
Flurazepam-induced sleep apnea syndrome in a patient with insomnia and mild sleep-related respiratory changes.
复制标题
氟西泮诱发的睡眠呼吸暂停综合征，患有失眠和轻度睡眠相关呼吸变化的患者。
DOI：
10.1097/00005053-198104000-00012
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
J. Gillin
中科院分区：
文献类型：
--
作者：
W. Mendelson;D. Garnett;J. Gillin
对一名有长期失眠和白天嗜睡病史的38岁男性进行睡眠脑电图和呼吸测量。在四次基线记录中，发现他每晚有7至18次主要阻塞性呼吸暂停，这一发现通常不被认为是病理学的指示。在他接受30 mg苯二氮卓类催眠药泮的前两个晚上，有22次和100次呼吸暂停，白天他变得非常困倦。停药后，他的临床状况改善，停药第4晚和第6晚，呼吸暂停次数减少至11次和6次。虽然呼吸抑制既不是固定不变的，也不是唯一的泮，这种情况下，它可能是一个临床上显着的问题与推荐的口服剂量在一些人。
Sleep EEG and respiratory measures were examined in a 38-year-old man with a long-standing history of insomnia and daytime sleepiness. He was found to have seven to 18 primarily obstructive apneas per night on four baseline recordings, a finding not generally considered to be indicative of pathology. On the first two nights on which he received 30 mg of the benzodiazepine hypnotic flurazepam, there were 22 and 100 apneas, and during the daytime he became extremely sleepy. Upon cessation of medication, his clinical condition improved, and the number of apneas decreased to 11 and 6 on withdrawal nights 4 and 6. Although respiratory depression is neither invariable nor unique to flurazepam, this case suggests that it may be a clinically significant problem with recommended oral doses in some individuals.