A highly selective and sensitive fluorescent chemosensor for detection of CN-, SO32- and Fe3+ based on aggregation-induced emission
A highly selective and sensitive fluorescent chemosensor for detection of CN-, SO32- and Fe3+ based on aggregation-induced emission
复制标题
一种基于聚集诱导发射的高选择性和灵敏荧光化学传感器，用于检测 CN-、SO32- 和 Fe3
DOI：
10.1039/c5tc02865e
复制
发表时间：
2016-01-01
影响因子：
6.4
通讯作者：
Liu, Ruiyuan
中科院分区：
文献类型：
--
作者：
Yang, Xiaodong;Chen, Xiuli;Liu, Ruiyuan
通过氰化物与三苯胺的亲核加成反应，设计并合成了一种具有聚集诱导发射的新型荧光化学传感器1。它具有显着的选择性和高灵敏度，并能够检测Fe 3+，CN-和SO 32-在几乎纯的水溶液中的低检测限为1.44 μ M，9.88 nM和0.107 μ M，分别。Job's plot和H-1 NMR数据表明1与Fe ~（3+）、CN ~-或SO ~（3 2-）的结合化学计量比为1：1。进一步的H-1 NMR滴定结果表明，1的两个氰基与Fe ~（3+）形成配位键，Fe ~（3+）的存在导致1的荧光猝灭，而CN-或SO_（32）-与乙烯基的亲核加成导致1的荧光猝灭。1的生物学应用也进行了评价，发现它表现出低细胞毒性和膜渗透性。此外，1还可制成检测Fe ~（3+）和CN ~-的试纸条，并用作活细胞中Fe ~（3+）的检测传感器。
A novel fluorescence chemosensor 1 with aggregation-induced emission was designed and synthesized through a nucleophilic addition reaction between cyanide and triphenylamine. It exhibited remarkable selectivity and high sensitivity and was able to detect Fe3+, CN- and SO32- in almost pure aqueous solution with low detection limits of 1.44 mu M, 9.88 nM and 0.107 mu M, respectively. Job's plot and H-1 NMR data showed that the binding stoichiometry of 1 with Fe3+, CN- or SO32- was 1:1. Further observations of H-1 NMR titration suggested that a coordination bond was formed between two cyano of 1 and Fe3+ which resulted in fluorescence quenching of 1 after detection of Fe3+, whereas the nucleophilic addition of cyanide or sulfite to the vinyl group was responsible for the fluorescent quenching of CN- or SO32- toward 1. The biological applications of 1 were also evaluated and it was found to exhibit low cytotoxicity and membrane permeability. In addition, 1 could also be made into test strips to detect Fe3+ and CN- and was employed as a sensor for detection Fe3+ in living cells.