Stereoselective construction of a 5-aza-spiro[2,4]heptane motif via catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate.
Stereoselective construction of a 5-aza-spiro[2,4]heptane motif via catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate.
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DOI：
10.1039/c0cc04329j
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发表时间：
2011-02
影响因子：
4.9
通讯作者：
Tang‐Lin Liu;Zhao-Lin He;H. Tao;Yuepeng Cai;Chun‐Jiang Wang
中科院分区：
文献类型：
--
作者：
Tang‐Lin Liu;Zhao-Lin He;H. Tao;Yuepeng Cai;Chun‐Jiang Wang
首次通过环亚丙基乙酸酯和偶氮甲碱叶立德的催化不对称1，3-偶极环加成反应，直接合成了高功能的5-氮杂螺[2，4]庚烷类化合物。
A direct and facile synthesis of highly functional 5-aza-spiro[2,4]heptanes, a valuable structural motif for drug discovery, is developed via catalytic asymmetric 1,3-dipolar cycloaddition of cyclopropylidene acetate and azomethine ylides for the first time.