Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
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DOI：
10.2174/1389200217666151210124713
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发表时间：
2016-01-01
影响因子：
2.3
通讯作者：
Makky, Essam A.
中科院分区：
文献类型：
--
作者：
AlMatar, Manaf;Batool, Tahira;Makky, Essam A.
背景：伤口愈合是一个复合的和重要的过程，其中失活的组织层和细胞结构进行自我修复。毛细支气管炎通常由呼吸道合胞病毒或人偏肺病毒引起;这种情况是细支气管的急性炎症损伤。出生前出现的心脏问题被称为先天性心脏病（CHD），而妊娠前糖尿病被认为是CHD的主要诱发因素。N-乙酰半胱氨酸（NAC）是一种氨基酸半胱氨酸的转化形式，当其被摄入体内时，可恢复细胞内天然抗氧化剂谷胱甘肽的水平，从而帮助细胞减少活性氧（ROS）的损伤作用。目的：在目前的交流中，NAC对伤口愈合，急性细支气管炎，和先天性心脏病（CHD）是批判性分析，通过审查其对这些疾病的各种目标的影响。NAC的多功能性概述了在审查的证据，从体外和体内study.Conclusion：总之，NAC可作为一种治疗剂，在治疗伤口愈合，急性细支气管炎和先天性心脏病（CHDs）。未来研究的重点应包括：（1）临床上应考虑NAC用于治疗伤口愈合;（2）研究NAC是否可单独使用或与胰岛素联合使用以预防妊娠前糖尿病婴儿的CHD;（3）评估NAC作为PAH治疗的潜在药物的应用。
Background: Wound healing is a composite and vital process in which devitalized tissue layers and cellular structures repair themselves. Bronchiolitis is generally prompted by respiratory syncytial virus or human metapneumovirus; this condition is an acute inflammatory injury of bronchioles. Heart problems that develop before birth are known as congenital heart defects (CHDs), and pregestational diabetes is considered a major predisposing factor of CHDs. N-Acetylcysteine (NAC) is a transformed kind of amino acid cysteine which restores the intracellular levels of the natural antioxidant glutathione when taken internally, thereby assisting the cells' ability to diminish the damaging effects of reactive oxygen species (ROS).Objective: In the present communication, NAC's therapeutic potential for wound healing, acute bronchiolitis, and congenital heart defects (CHDs) is critically analyzed by reviewing its effect on the various targets of these diseases. The multifunctional nature of NAC is outlined in a review of evidence from in vitro and in vivo studies.Conclusion: In conclusion, NAC could be used as a therapeutic agent in the treatment of wound healing, acute bronchiolitis and congenital heart defects (CHDs). The focus of future research should be the following; (1) to examine NAC clinically to be considered in the treatment of wound healing; (2) to investigate whether NAC could be used alone or with insulin to prevent CHDs in infants with pregestational diabetes; (3) to evaluate the application of NAC as a potential agent for PAH treatment.