Prevention of Haemophilus influenzae type b infections in high-risk infants treated with bacterial polysaccharide immune globulin.
Prevention of Haemophilus influenzae type b infections in high-risk infants treated with bacterial polysaccharide immune globulin.
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使用细菌多糖免疫球蛋白治疗的高危婴儿预防 b 型流感嗜血杆菌感染。
DOI：
10.1056/nejm198710083171503
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Foster,S
中科院分区：
文献类型：
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作者：
Santosham,M;Reid,R;Ambrosino,DM;Wolff,MC;Almeido-Hill,J;Priehs,C;Aspery,KM;Garrett,S;Croll,L;Foster,S
阿帕奇印第安婴儿有很高的频率流感嗜血杆菌B型（HiB）和肺炎球菌感染。这些婴儿中40%的Hib感染发生在6个月之前，此时主动免疫可能没有保护作用。评价人超免疫球蛋白被动免疫的效果（细菌多糖免疫球蛋白[BPIG]），我们以双盲方式随机分配703名婴儿，在2，6，在4、6和10月龄时，BPIG接受者的Hib-antibody水平显著高于安慰剂接受者（P<0.001）。在BPIG后的前90天内，
Apache Indian infants have a high frequency ofHaemophilus influenzaetype b (Hib) and pneumococcal infections. Forty percent of Hib infections in these infants occur before the age of six months, when active immunization may not be protective. To evaluate the efficacy of passive immunization with a human hyperimmune globulin (bacterial polysaccharide immune globulin [BPIG]) prepared from the plasma of immunized adult donors, we randomly assigned 703 infants in a double-blind fashion to receive 0.5 ml of BPIG per kilogram of body weight (n = 353) or 0.5 ml of saline (n = 350) intramuscularly at 2, 6, and 10 months of age.Hib-antibody levels were significantly higher in BPIG recipients than in placebo recipients at 4, 6, and 10 months of age (P<0.001). During the first 90 days after BPIG or