Glutamate-evoked jaw muscle pain as a model of persistent myofascial TMD pain?
Glutamate-evoked jaw muscle pain as a model of persistent myofascial TMD pain?
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DOI：
10.1016/j.archoralbio.2008.01.008
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发表时间：
2008-07-01
影响因子：
3
通讯作者：
Suensson, Peter
中科院分区：
文献类型：
--
作者：
Castrillon, Eduardo E.;Cairns, Brian E.;Suensson, Peter
目的：比较疼痛相关的措施和心理社会变量之间谷氨酸诱发的下颌肌肉疼痛的健康受试者（HS）和患者持续性肌筋膜颞下颌关节紊乱病（TMD）pain.Design：47名女性HS和10名女性患者持续性肌筋膜TMD疼痛参加。HS接受谷氨酸盐注射到咬肌中以模拟持续性肌筋膜TMD疼痛。参与者填写应对策略问卷（CSQ）、症状自评量表（SCL-90）和麦吉尔疼痛问卷（MPQ）。采用电子视觉模拟量表（VAS）评估疼痛强度。测量疼痛描绘面积、不愉快数字评定量表（NRS）评分、压迫痛阈值（PPT）和压迫痛耐受力（PPTOL）。结果：CSQ控制、减少、转移注意力、增加行为活动、躯体化5个因子分，两组比较差异有统计学意义（P <0.05）。两组间VAS疼痛峰值、不愉快NRS和MPQ评分无显著差异，但TMD患者PPT和PPTOL显著降低。TMD患者VAS疼痛峰值与CSQ灾难化评分、SCL-90躯体化呈显著正相关。患者的PPT和PPTOLs评分与CSQ重新解释疼痛感觉评分呈正相关，PPT与CSQ祈祷/希望scores.Conclusions：谷氨酸诱发的疼痛反应在HS和持续性肌筋膜TMD疼痛有相似的感觉辨别和情感不愉快的成分，但不同的心理社会功能。这项研究表明，基于谷氨酸注射到肌肉中的实验设计可以为阐明持续性肌筋膜疼痛状况提供适当的模型。(C)2008爱思唯尔有限公司保留所有权利。
Objective: Compare pain-related measures and psychosocial variables between glutamate-evoked jaw muscle pain in healthy subjects (HS) and patients with persistent myofascial temporomandibular disorder (TMD) pain.Design: Forty-seven female HS and 10 female patients with persistent myofascial TMD pain participated. The HS received an injection of glutamate into the masseter muscle to model persistent myofascial TMD pain. Participants filled out a coping strategies questionnaire (CSQ), the symptom checklist 90 (SCL-90) and McGill pain questionnaire (MPQ). Pain intensity was assessed on an electronic visual analogue scale (VAS). Pain-drawing areas, numerical rating scale (NRS) scores of unpleasantness, pressure pain thresholds (PPTs) and pressure pain tolerance (PPTOL) were measured. Unpaired t-tests and correlation tests were used for analyses.Results: The groups were significantly different when comparing the CSQ scores of control, decrease, diverting attention, increase of behavioural activities and somatization. The peak VAS pain, NRS of unpleasantness and MPQ scores were not significantly different between groups, but PPT and PPTOL were significantly lower in the TMD patients. Significant positive correlations were found in the TMD patients between peak VAS pain and CSQ catastrophizing score and SCL-90 somatization. The scores of PPTs and PPTOLs, in patients showed positive correlations with CSQ reinterpreting pain sensations scores and PPTs correlated with CSQ praying/hoping scores.Conclusions: Glutamate-evoked pain responses in HS and persistent myofascial TMD pain have similar Sensory-discriminative and affective-unpleasantness components but differ in psychosocial features. This study suggests that experimental designs based on glutamate injection into muscle can provide an appropriate model for elucidating persistent myofascial pain conditions. (C) 2008 Elsevier Ltd. All rights reserved.