THE ANEMIA OF P-FALCIPARUM MALARIA
THE ANEMIA OF P-FALCIPARUM MALARIA
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DOI：
10.1111/j.1365-2141.1980.tb05956.x
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发表时间：
1980-01-01
影响因子：
6.5
通讯作者：
HUGHES, M
中科院分区：
文献类型：
--
作者：
ABDALLA, S;WEATHERALL, DJ;HUGHES, M
对一组患有恶性疟疾的冈比亚幼儿的血液学变化进行了分析。急性感染儿童的贫血在治疗后期间最为明显。尽管许多患者在患病期间直接库姆斯试验呈阳性，但尚不清楚治疗后发生的贫血是否具有免疫基础。第二组儿童表现出截然不同的血液学结果。他们似乎患有更慢性的恶性疟原虫感染，就诊时患有严重贫血，骨髓中出现明显的红细胞生成异常变化，治疗后出现完全网织红细胞反应和血红蛋白升高。第三组儿童的血液学异常程度介于急性组和慢性组之间。这些发现表明，造成恶性疟原虫疟疾贫血的病理生理机制在疾病的不同阶段是不同的。
The hematological changes in a group of young Gambian children with P. falciparum malaria were analyzed. In children with acute infection anemia was most marked during the period after treatment. Although many of these patients developed a positive direct Coombs test during this period of the illness it not clear whether the anemia which occurs after treatment has an immune basis. A 2nd group of children showed quite different hematological findings. They appear to have a more chronic form of P. falciparum malaria infection, were profoundly anemic at presentation, showed gross dyserythropoietic changes in their bone marrows, and had a full reticulocyte response and rise in Hb after treatment. A 3rd group of children were encountered whose hematological abnormalities were intermediate to those of the acute and chronic groups. These findings indicate that the pathophysiological mechanisms responsible for the anemia of P. falciparum malaria are different at different stages of the illness.