Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring
Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring
复制标题
DOI：
10.1016/j.ypmed.2006.01.015
复制
发表时间：
2006-05-01
影响因子：
5.1
通讯作者：
Toyoshima, Hideaki
中科院分区：
文献类型：
--
作者：
Wada, Keiko;Tamakoshi, Koji;Toyoshima, Hideaki
背景高血压、糖尿病和血脂异常的家族聚集性已有大量报道。然而，只有少数研究评估了父母的病史在多大程度上参与了这些疾病的聚集。2002年，在5010名33-66岁的日本男性和女性的基础上，评估了父母高血压、糖尿病和血脂异常病史与个体中高血压、高血糖和血脂异常聚集之间的关联。危险因素群被定义为具有三种临床疾病中至少两种的患者。与父母无3种疾病史者相比，父母有1、2、3种或3种以上疾病史者的危险因素聚集度分别为1.25（95%CI：1.07，1.47）、1.46（95%CI：1.47）、1.46（95%CI：1.47）。在调整混杂因素后，分别高出1.41（95%CI：0.95，2.11）倍。按1、2和3项母亲病史计算的OR为1.33（95%CI：1. 33）。12，1.58），1.65（95% CI：1. 16，2.35）和1.69（95% CI：0.64，4.42）（趋势P < 0.001）。但父亲病史的多少与危险因素聚集无关。我们的结论是，家族史，特别是母亲的历史，是一个重要的援助，代谢紊乱的预防策略和公共卫生实践。(c)2006年爱思唯尔公司All rights reserved.
Background. Familial aggregation of hypertension, diabetes and dyslipidemia has been well reported. However, only a few studies have assessed to what extent parental histories were involved in the clustering of these diseases.Method. In 2002, associations between parental histories of hypertension, diabetes and dyslipidemia and the clustering of high blood pressure, hyperglycemia and dyslipidemia in individuals were assessed on the basis of 5010 Japanese men and women aged 33-66 years. Risk factor clusters were defined as those having at least two of the three clinical disorders.Results. Compared with persons with no parental history of the three diseases, those who had 1, 2 and 3 or more parental histories had risk factor clusters, 1.25 (95% CI: 1.07, 1.47), 1.46 (95% CI: 1. 16, 1.84) and 1.41 (95% CI: 0.95, 2.11) times higher, respectively, after adjusting for confounding factors. ORs by 1, 2 and 3 of maternal history were 1.33 (95% CI: 1. 12, 1.58), 1.65 (95% CI: 1. 16, 2.35) and 1.69 (95% CI: 0.64, 4.42), respectively (trend P < 0.001). However, the number of paternal history was not associated with risk factor clusters.Conclusion. We conclude that familial history, particularly maternal history, is an important aid to prevention strategy and public health practice for metabolic disorders. (c) 2006 Elsevier Inc. All rights reserved.