Removal of dental alloys and titanium attenuates trace metals and biological effects on liver and kidney
Removal of dental alloys and titanium attenuates trace metals and biological effects on liver and kidney
复制标题
去除牙科合金和钛可减弱微量金属以及对肝脏和肾脏的生物影响
DOI：
10.1016/j.chemosphere.2019.125205
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发表时间：
2020
期刊：
影响因子：
8.8
通讯作者：
Cheng Hui
中科院分区：
文献类型：
--
作者：
Pan Yu;Lin Yunzhi;Jiang Lei;Lin Honglei;Xu Caiming;Lin Donghong;Cheng Hui
为了确定是否可以通过去除镍铬（Ni-Cr）合金、钴铬（Co-Cr）合金和商业纯钛（CP-Ti）来减少或终止牙科合金对肝脏和肾脏的潜在影响，根据ISO 10993-10将它们放置在叙利亚仓鼠的脸颊袋中。然后，在去除牙合金或不去除牙合金的情况下，测定血液中痕量金属的峰值/平台和结束时间。根据这些时间点，检测了微量金属及其对肝脏和肾脏的影响。我们发现，这些牙科合金和钛释放的微量金属在血液、肝脏和肾脏中短暂积累，但对肝脏和肾脏的组织病理学没有影响。虽然肝脏和肾脏的功能受损，但与对照的叙利亚仓鼠相比，这些组织的功能在临床上似乎是可以接受的。此外，去除Ni-Cr和Co-Cr合金可以终止肾细胞的凋亡作用，去除Ni-Cr合金也可以消除肝细胞的凋亡作用。而Co-Cr合金对肝细胞的影响是暂时的，可自行恢复。综上所述，镍基、钴基牙科合金和钛对肝脏和肾脏的组织病理学和功能没有影响。此外，Ni-Cr和Co-Cr合金在肝脏和肾脏中诱导短暂的微量金属积累和凋亡效应，可以通过去除合金来减少或终止，而CP-Ti具有良好的生物相容性。
To determine whether the potential effects on liver and kidney caused by dental alloys could be reduced or terminated by the removal of nickel-chromium (Ni-Cr) alloy, cobalt-chromium (Co-Cr) alloy, and commercially pure titanium (CP-Ti), they were placed in the cheek pouches of Syrian hamsters according to ISO 10993-10. Then, the peak/plateau and end times of trace metals in the blood were determined with or without the removal of the dental alloys. Based on these time points, the trace metals and their effects on liver and kidney were examined. We found that trace metals released from these dental alloys and titanium were accumulated transiently in the blood, liver, and kidney but had no effect on the histopathology of the liver or kidney. Although the functions of the liver and kidney were compromised, the function of these tissues seemed to be clinically acceptable compared to those in control Syrian hamsters. In addition, the apoptotic effect on renal cells was terminated by removing the Ni-Cr and Co-Cr alloys, and that on hepatocytes was also eliminated by removing the Ni-Cr alloy. In contrast, the effect of the Co-Cr alloy on hepatocytes was temporary and recovered by itself. Taken together, Ni- and Co-based dental alloys and titanium have no effect on the histopathology or function of liver and kidney. Moreover, Ni-Cr and Co-Cr alloys induce transient trace metal accumulation and apoptotic effects in liver and kidney, which can be reduced or terminated by the removal of the alloys, while CP-Ti shows favorable biocompatibility.