Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development
Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development
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DOI：
10.1111/j.1365-2222.2007.02856.x
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发表时间：
2008-01-01
影响因子：
6.1
通讯作者：
Prescott, S. L.
中科院分区：
文献类型：
--
作者：
Martino, D. J.;Currie, H.;Prescott, S. L.
背景：早期肠道定植模式的变化通过对粘膜和全身免疫功能的影响，与过敏性疾病的易感性有关。方法观察6月龄儿童的定植模式和黏膜IgA生成与早期暴露、全身免疫发育和早期过敏结局的关系。这是在一组（n = 189）自出生以来接受嗜酸乳杆菌或安慰剂的队列中进行的。结果：在12月龄前对一种或多种过敏原过敏的儿童，在6月龄时总IgA水平（而不是分泌IgA水平）显著升高（P = 0.024），但这与益生菌治疗无关。定植模式与IgA（总IgA或分泌IgA）水平或过敏结果（致敏、特应性皮炎或食物过敏）之间没有关系。母乳喂养和使用酸奶或益生菌补充剂与“有利”乳酸菌和双歧杆菌物种的比例显著增加独立相关。前6个月的剖腹产和抗生素使用与细菌定植的显著变化无关。较高比例的“有利”细菌（特别是双歧杆菌）与大多数细胞因子对过敏原的反应减少有关，但调节细胞标记物（P = 0.009）和转化生长因子- β (P = 0.016)的表达增加。结论：“有利”定植，特别是双歧杆菌，与细胞免疫功能的影响有关，但与粘膜免疫（分泌IgA）或降低过敏性疾病的风险无关。
Background Variations in early intestinal colonization patterns have been implicated in the predispostion to allergic disease through effects on mucosal and systemic immune function.Methods Colonization patterns and mucosal IgA production at 6 months of age were examined in relation to early exposures, systemic immune development and early allergic outcomes. This was performed in a cohort (n = 189) who had received either Lactobacillus acidophilus or a placebo since birth.Results Children who developed sensitization to one or more allergens by 12 months of age had significantly higher total (but not secretory) IgA levels at 6 months (P = 0.024), but this was independent of probiotic treatment. There were no relationships between colonization patterns and IgA (total or secretory IgA) levels or allergic outcomes (sensitization, atopic dermatitis or food allergies). Breastfeeding, and the use of yoghurt or probiotic supplements were independently associated with significantly higher proportions of 'favourable' lactobacilli and bifidobacteria species. Caesarean delivery and the use of antibiotics during the first 6 months were not associated with significant variations in colonization. Higher proportions of 'favourable' bacteria (notably bifidobacteria) were associated with reduced production of most cytokine response to allergens, but increased expression of regulatory cell markers (P = 0.009) and transforming growth factor-beta (P = 0.016).Conclusion 'Favourable' colonization, particularly with bifidobacteria, was associated with effects on cellular immune function, but this was not associated with mucosal immunity (secretory IgA) or reduced risk of allergic disease.