Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis, and Eczema in Adolescents International Study of Asthma and Allergies in Childhood Phase Three
Acetaminophen Use and Risk of Asthma, Rhinoconjunctivitis, and Eczema in Adolescents International Study of Asthma and Allergies in Childhood Phase Three
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DOI：
10.1164/rccm.201005-0757oc
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发表时间：
2011-01-15
影响因子：
24.7
通讯作者：
Stewart, Alistair W.
中科院分区：
文献类型：
--
作者：
Beasley, Richard W.;Clayton, Tadd O.;Stewart, Alistair W.
基本原理有流行病学证据表明，使用对乙酰氨基酚可能会增加患哮喘的风险。目的：调查全球不同人群中13至14岁儿童中与目前使用对乙酰氨基酚相关的哮喘和其他过敏性疾病的风险。方法：作为儿童哮喘和过敏症国际研究（ISAAC）第三阶段的一部分，13至14岁的儿童完成了书面和视频问卷，获得了关于哮喘、鼻结膜炎、和湿疹，和一份书面的环境调查问卷，获得推定的危险因素，包括使用对乙酰氨基酚在过去12个months. Measures和主要结果：主要结果的措施是目前的哮喘症状与对乙酰氨基酚使用logistic回归计算的比值比（OR）。共有来自50个国家113个中心的322，959名青少年儿童参加了研究。在多变量分析中，近期使用对乙酰氨基酚与当前哮喘症状的风险增加呈剂量依赖性相关（中度和高度与未使用的OR分别为1.43 [95%置信区间，1.33-1.531和2.51 [95%置信区间，2.33-2.70]）。对乙酰氨基酚的使用也与鼻结膜炎和湿疹的当前症状的风险增加的一个依赖性的风险增加。结论：对乙酰氨基酚的使用可能是一个重要的风险因素的发展和/或维持哮喘，鼻结膜炎，湿疹在青少年儿童。
Rationale There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma.Objectives: To investigate the risk of asthma and other allergic disorders associated with the current use of acetaminophen in 13- to 14-year-old children in different populations worldwide.Methods: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three, 13- to 14-year-old children completed written and video questionnaires obtaining data on current symptoms of asthma, rhinoconjunctivitis, and eczema, and a written environmental questionnaire obtaining data on putative risk factors, including acetaminophen use in the past 12 months.Measurements and Main Results: The primary outcome measure was the odds ratio (OR) of current asthma symptoms associated with acetaminophen use calculated by logistic regression. A total of 322,959 adolescent children from 113 centers in 50 countries participated. In the multivariate analyses the recent use of acetaminophen was associated with an exposure-dependent increased risk of current asthma symptoms (OR, 1.43 [95% confidence interval, 1.33-1.531 and 2.51 [95% confidence interval, 2.33-2.70] for medium and high versus no use, respectively). Acetaminophen use was also associated with an exposure-dependent increased risk of current symptoms of rhinoconjunctivitis and eczema.Conclusions: Acetaminophen use may represent an important risk factor for the development and/or maintenance of asthma, rhinoconjunctivitis, and eczema in adolescent children.