The medtronic MiniMed gold continuous glucose monitoring system: An effective means to discover hypo- and Hyperglycemia in children under 7 years of age
The medtronic MiniMed gold continuous glucose monitoring system: An effective means to discover hypo- and Hyperglycemia in children under 7 years of age
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DOI：
10.1089/dia.2007.0026
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Buckingham, Bruce A.
中科院分区：
文献类型：
--
作者：
Gandrud, Laura M.;Xing, Dongyuan;Buckingham, Bruce A.
背景：尚未使用连续血糖监测对 7 岁以下 1 型糖尿病儿童的血糖模式进行充分研究。我们的目标是利用连续血糖监测来评估该年龄段低血糖的发生率以及餐后血糖模式。方法：19 名儿童在大约 6 个月内使用美敦力 MiniMed（加利福尼亚州北岭）CGMS((R)) System Gold (TM) 3 至 7 次。结果：使用 19 名儿童（9 名女孩和 10 名男孩；平均年龄 4.8 +/- 1.4 岁，范围 1.6-6.8 岁） CGMS 102次，提供434天的数据；根据 CGMS Solutions 软件版本 3.0，79% 的天数是最佳的。轻度低血糖（50% 早餐后血糖 = 2 mg/dL/min。血红蛋白 Alc 水平 >= 8% 的儿童餐后血糖浓度较高。在降低餐后高血糖方面，连续皮下胰岛素输注治疗比每日多次注射治疗没有显着优势。结论：糖尿病幼儿的 CGMS 追踪显示频繁的轻度夜间低血糖和显着的餐后低血糖。高血糖，餐后血糖迅速上升，早餐后血糖上升速度最快，餐后血糖最严重。
Background: The glycemic patterns of children less than 7 years with type 1 diabetes have not been well studied using continuous glucose monitoring. Our goal was to assess the incidence of hypoglycernia as well as postprandial glycemic patterns in this age group utilizing continuous glucose monitoring.Methods: Nineteen children used the Medtronic MiniMed (Northridge, CA) CGMS((R)) System Gold (TM) on three to seven occasions over approximately 6 months.Results: Nineteen children (nine girls and 10 boys; mean age 4.8 +/- 1.4 years, range 1.6-6.8 years) used the CGMS 102 times, providing 434 days of data; 79% of days were optimal based on CGMS Solutions software version 3.0. Mild hypoglycernia (glucose = 2 mg/dL/min following 50% of breakfasts. Children with hemoglobin Alc levels >= 8% had higher postprandial glucose concentrations. There was no significant advantage of continuous subcutaneous insulin infusion therapy over multiple daily injection therapy in decreasing postprandial hyperglycernia.Conclusions: CGMS tracings from young children with diabetes demonstrate frequent mild nocturnal hypoglycernia and significant postprandial hyperglycernia, with a rapid rise in glucose following the meal. The most rapid rate of rise and the most severe postprandial hyperglycemia occurred after breakfast.