POLYMORPHS INFILTRATE GLOMERULI IN MESANGIAL IGA GLOMERULONEPHRITIS
POLYMORPHS INFILTRATE GLOMERULI IN MESANGIAL IGA GLOMERULONEPHRITIS
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DOI：
10.1038/ki.1989.308
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发表时间：
1989-12-01
影响因子：
19.6
通讯作者：
BIRCHALL, I
中科院分区：
文献类型：
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作者：
KINCAIDSMITH, P;NICHOLLS, K;BIRCHALL, I
在肉眼血尿发作期间，伊加肾病患者通常在肾小球毛细血管中具有多形核中性粒细胞（PMN）以及纤维蛋白和单核细胞。我们对54例伊加肾病患者的肾小球中性粒细胞和巨噬细胞浸润进行了定量分析，这些患者在肉眼血尿后30天内进行了肾活检。对照活检（N = 22）来自伊加肾病和尿红细胞计数低于50，000/ml的患者。分别使用单克隆抗体FMC 10和HAM 56定量PMN单核细胞/巨噬细胞。在重度血尿患者中，45.9 ±。3.4%（平均值±）SE）为阳性（对照组10.5 ± 0.01）。2.8%，P = 0.001），平均PMN计数/肾小球为1.10 ± 0.01。0.20（对照0.13 ± 0.15）。0.03，P = < 0.001）。65.6 .+-.在重度血尿组中，9.7%的肾小球为单核细胞阳性（对照组40.0 ± 0.5%）。8.4，P < 0.05），每个肾小球的平均单核细胞计数为1.6 ± 0.05。0.2（对照0.6 ± 0.5）。0.1，P < 0.01）。我们的结论是，在急性期的系膜伊加肾病，中性粒细胞和单核细胞的存在，并推测参与肾小球损伤。
During episodes of macroscopic hematuria, patients with IgA nephropathy commonly have polymorphonuclear neutrophils (PMNs) as well as fibrin and mononuclear cells in glomerular capillaries. We quantitated PMN and macrophage infiltration in glomeruli of 54 patients with IgA nephropathy in whom renal biopsies were obtained within 30 days of macroscopic hematuria. Control biopsies (N = 22) were from patients with IgA nephropathy and urinary erythrocyte counts below 50,000/ml. PMN monocyte/macrophages were quantitated using the monoclonal antibodies FMC10 and HAM56, respectively. In patients with heavy hematuria, 45.9 .+-. 3.4% (mean .+-. SE) of glomeruli were positive for PMNs (control 10.5 .+-. 2.8%, P = 0.001) with a mean PMN count/glomerulus of 1.10 .+-. 0.20 (control 0.13 .+-. 0.03, P = < 0.001). 65.6 .+-. 9.7% Of the glomeruli were positive for monocytes in the heavy hematuria group (control 40.0 .+-. 8.4, P < 0.05) with the mean monocyte count per glomerulus being 1.6 .+-. 0.2 (control 0.6 .+-. 0.1, P < 0.01). We conclude that, in the acute phase of mesangial IgA nephropathy, PMN and monocytes are present and presumably participate in glomerular injury.