Tendon tissue engineering: progress, challenges, and translation to the clinic.
Tendon tissue engineering: progress, challenges, and translation to the clinic.
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发表时间：
2011-06
影响因子：
1.9
通讯作者：
J. Shearn;Kirsten R. C. Kinneberg;N. Dyment;M. Galloway;Keith Kenter;Christopher Wylie;David L. Butler
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文献类型：
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作者：
J. Shearn;Kirsten R. C. Kinneberg;N. Dyment;M. Galloway;Keith Kenter;Christopher Wylie;David L. Butler
组织工程领域在理解组织工程构建物（TEC）的不同方面和培养过程如何影响最终肌腱修复方面取得了很大进展。然而，在开发将导致临床有效和商业上成功的产品的策略方面仍然存在重大挑战。为了提高修复质量，更好地了解正常发育，以及它与成人肌腱愈合的不同之处，可能会提供改善组织工程的策略。随着肌腱组织工程的不断改进，该领域需要采用更多临床相关的肌腱损伤模型，如退行性肌腱。我们需要将成功转化为更大的动物模型，以开始探索我们治疗的临床意义。通过改进用于验证TEC的模型，我们可以帮助说服最棘手的客户（外科医生），我们的产品将在临床上有效。当我们在肌肉骨骼组织工程中解决这些挑战时，该领域仍然需要解决实验室开发的产品的商业化问题。TEC商业化面临着许多挑战，因为每个损伤和患者都是独特的。这篇综述旨在为组织工程师提供与工程肌腱修复相关的重要问题和生产临床成功产品的潜在策略的总结。
The tissue engineering field has made great strides in understanding how different aspects of tissue engineered constructs (TECs) and the culture process affect final tendon repair. However, there remain significant challenges in developing strategies that will lead to a clinically effective and commercially successful product. In an effort to increase repair quality, a better understanding of normal development, and how it differs from adult tendon healing, may provide strategies to improve tissue engineering. As tendon tissue engineering continues to improve, the field needs to employ more clinically relevant models of tendon injury such as degenerative tendons. We need to translate successes to larger animal models to begin exploring the clinical implications of our treatments. By advancing the models used to validate our TECs, we can help convince our toughest customer, the surgeon, that our products will be clinically efficacious. As we address these challenges in musculoskeletal tissue engineering, the field still needs to address the commercialization of products developed in the laboratory. TEC commercialization faces numerous challenges because each injury and patient is unique. This review aims to provide tissue engineers with a summary of important issues related to engineering tendon repairs and potential strategies for producing clinically successful products.