NITRIC-OXIDE MEDIATES NETWORK OSCILLATIONS OF OLFACTORY INTERNEURONS IN A TERRESTRIAL MOLLUSK
NITRIC-OXIDE MEDIATES NETWORK OSCILLATIONS OF OLFACTORY INTERNEURONS IN A TERRESTRIAL MOLLUSK
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DOI：
10.1038/369061a0
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发表时间：
1994-05-05
期刊：
影响因子：
64.8
通讯作者：
GELPERIN, A
中科院分区：
文献类型：
--
作者：
GELPERIN, A
神经元间信使一氧化氮(1，2)(NO)可能在嗅觉信息处理中起中心作用(3)。哺乳动物嗅球中的一些回路元件不含合酶(4)或其功能等价物NADPH黄递酶(5-7)。NO对嗅球细胞、兴奋性或电路动力学的影响尚不清楚，尽管对其他节律细胞(8)和电路(9)没有任何影响。他们利用陆生软体动物嗅觉加工的主要中枢前脑(PC)叶，研究了NO在中枢嗅觉加工中的作用(10，11)。就像哺乳动物嗅球在气味刺激时一样，软体动物PC叶的电活动的基本动力学是振荡(12-14)。在这里，我报告了NO的一个强制性作用，那就是LIMAX MAXUS的PC叶的振荡动力学。一氧化氮介导的嗅觉振荡可能与Limax(15，16)高度发达的嗅觉敏感性和嗅觉学习能力有关。
THE interneuronal messenger nitric oxide(1,2) (NO) may play a central role in the processing of olfactory information(3). Several circuit elements in the mammalian olfactory bulb contain NO synthase(4) or its functional equivalent, NADPH diaphorase(5-7). The effects of NO on cellular,excitability or circuit dynamics in the olfactory bulb are unknown, although NO effects on other rhythmic cells(8) and circuits(9) have been described. T have studied the role of NO in central olfactory processing using the procerebral (PC) lobe, the major central site of odour processing in terrestrial molluscs(10,11). As in the mammalian olfactory bulb during odour stimulation, the basic dynamics of electrical activity in the molluscan PC lobe is an oscillation(12-14). Here I report an obligatory role for NO is the oscillatory dynamics of the PC lobe of Limax maximus. Nitric oxide mediation of the olfactory oscillation may relate to the highly developed odour sensitivity and odour-learning ability of Limax(15,16).