The emerging roles of the DDX41 protein in immunity and diseases.
The emerging roles of the DDX41 protein in immunity and diseases.
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DDX41 蛋白在免疫和疾病中的新作用
DOI：
10.1007/s13238-016-0303-4
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发表时间：
2017-02
期刊：
影响因子：
21.1
通讯作者：
Ouyang S
中科院分区：
文献类型：
--
作者：
Jiang Y;Zhu Y;Liu ZJ;Ouyang S
RNA解旋酶几乎参与RNA的各个方面，从转录到RNA降解。DExD/H-box解旋酶是SF 2解旋酶超家族中最大的一个成员，具有两个保守的RecA样结构域。近年来，这些蛋白质越来越多地被发现具有意想不到的功能。它们不仅在先天免疫应答中起重要作用，而且在癌症和慢性丙型肝炎等疾病中也起重要作用。本文就SF 2超家族成员之一的死亡盒蛋白DDX 41的研究进展作一综述。在细菌或病毒感染后，DNA或环状二GMP被释放到细胞中。在Tyr 414被BTK激酶磷酸化后，DDX 41将作为识别入侵者的传感器，随后诱导I型干扰素（IFN）。在免疫应答后，DDX 41被E3连接酶TRIM 21降解，使用DDX 41的Lys 9和Lys 115作为泛素化位点。除了在先天免疫中的作用外，DDX 41还与疾病有关。在骨髓增生异常综合征（MDS）和/或急性髓细胞白血病（AML）患者中发现了越来越多的DDX 41基因的遗传性和获得性突变。该综述的重点是DDX 41，以及它的同源物Abstrakt在果蝇，这是重要的生存在整个生命周期的各个阶段的苍蝇。
RNA helicases are involved in almost every aspect of RNA, from transcription to RNA decay. DExD/H-box helicases comprise the largest SF2 helicase superfamily, which are characterized by two conserved RecA-like domains. In recent years, an increasing number of unexpected functions of these proteins have been discovered. They play important roles not only in innate immune response but also in diseases like cancers and chronic hepatitis C. In this review, we summarize the recent literatures on one member of the SF2 superfamily, the DEAD-box protein DDX41. After bacterial or viral infection, DNA or cyclic-di-GMP is released to cells. After phosphorylation of Tyr414 by BTK kinase, DDX41 will act as a sensor to recognize the invaders, followed by induction of type I interferons (IFN). After the immune response, DDX41 is degraded by the E3 ligase TRIM21, using Lys9 and Lys115 of DDX41 as the ubiquitination sites. Besides the roles in innate immunity, DDX41 is also related to diseases. An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (MDS/AML) patients. The review focuses on DDX41, as well as its homolog Abstrakt in Drosophila, which is important for survival at all stages throughout the life cycle of the fly.