Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation
Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation
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DOI：
10.18632/aging.102074
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发表时间：
2019-07-31
期刊：
影响因子：
5.2
通讯作者：
Deuchars, Jim
中科院分区：
文献类型：
--
作者：
Bretherton, Beatrice;Atkinson, Lucy;Deuchars, Jim
衰老与自主神经功能减弱有关。经皮迷走神经刺激（tVNS）改善了健康年轻参与者的自主神经功能。因此，我们研究了年龄≥ 55岁的志愿者接受单次tVNS治疗（研究1和2）和每天一次tVNS治疗两周（研究3）的效果。使用耳屏上的改良表面电极进行tVNS，并连接到经皮电神经刺激（TENS）机。研究1：参与者（n=14）接受了单次tVNS和假手术。研究2：所有参与者（n=51）均接受了单次tVNS治疗。研究3：参与者（n=29）每天接受tVNS，持续两周。心率变异性和压力反射敏感性。在研究3中评估了生活质量（QoL）、情绪和睡眠。与假手术相比，tVNS促进迷走神经张力测量的增加，并且与压力反射敏感性的更大增加相关。两周的每日tVNS改善了自主神经功能的测量，以及生活质量，情绪和睡眠的某些方面。重要的是，研究结果表明，在基线交感神经患病率较高的参与者中，自主平衡指标的改善更为明显。这表明，有可能确定哪些人可能从tVNS中获得重大利益。
Ageing is associated with attenuated autonomic function. Transcutaneous vagal nerve stimulation (tVNS) improved autonomic function in healthy young participants. We therefore investigated the effects of a single session of tVNS (studies 1 and 2) and tVNS administered daily for two weeks (study 3) in volunteers aged >= 55 years. tVNS was performed using modified surface electrodes on the tragus and connected to a transcutaneous electrical nerve stimulation (TENS) machine. Study 1: participants (n=14) received a single session of tVNS and sham. Study 2: all participants (n=51) underwent a single session of tVNS. Study 3: participants (n=29) received daily tVNS for two weeks. Heart rate variability and baroreflex sensitivity were derived. Quality of life (QoL), mood and sleep were assessed in study 3. tVNS promoted increases in measures of vagal tone and was associated with greater increases in baroreflex sensitivity than sham. Two weeks of daily tVNS improved measures of autonomic function, and some aspects of QoL, mood and sleep. Importantly, findings showed that improvements in measures of autonomic balance were more pronounced in participants with greater baseline sympathetic prevalence. This suggests it may be possible to identify individuals who are likely to encounter significant benefits from tVNS.