Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood
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DOI：
10.1093/gerona/gly121
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发表时间：
2019-03-01
影响因子：
5.1
通讯作者：
Morey, Miriam C.
中科院分区：
文献类型：
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作者：
Parker, Daniel;Sloane, Richard;Morey, Miriam C.
衰老的特点是有害的免疫和代谢变化，但这些变化的发生尚不清楚。我们从 30 岁开始测量成年人的免疫和代谢生物标志物。据我们所知，这是第一项评估 30 岁至 80 岁以上成年人的这些生物标志物的研究。对 961 名成年人的生物标志物进行了量化。肿瘤坏死因子 α (TNF-)、肿瘤坏死因子受体 I (TNFR-I)、肿瘤坏死因子受体 II (TNFR-II)、白细胞介素 (IL)-2、IL-6、VCAM-I、D-二聚体、G-CSF、激活调节、正常 T 细胞表达和分泌 (RANTES)、基质金属蛋白酶 3 (MMP-3)、脂联素和对氧磷酶活性通过以下方法测量酶联免疫吸附试验。通过质谱法测量酰基肉碱和氨基酸 (AA)，并使用主成分分析 (PCA) 将其简化为单因素。单独分析甘氨酸。通过以性别、种族和体重指数（BMI）作为协变量的线性回归分析年龄和生物标志物之间的关系。年龄与 TNF-、TNFR-I、TNFR-II、IL-6、IL-2、VCAM-1、D-二聚体、MMP-3、脂联素、酰基肉碱和 AA 呈正相关。年龄与 G-CSF、RANTES 和对氧磷酶活性呈负相关。除 IL-2、VCAM-1、RANTES、对氧磷酶活性和 AA 因子外，BMI 对所有生物标志物均显着。排除 MMP-3 之外，BMI 越大，生物标志物浓度的潜在不利变化相关。免疫和代谢生物标志物与年龄相关的变化早在三十多岁就开始出现，已知与老年人的不良预后有关。
Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers in adults aged 30 to over 80. Biomarkers were quantified in 961 adults. Tumor necrosis factor alpha (TNF-), tumor necrosis factor receptor I (TNFR-I), tumor necrosis factor receptor II (TNFR-II), interleukin (IL)-2, IL-6, VCAM-I, D-Dimer, G-CSF, regulated on activation, normal T cell expressed and secreted (RANTES), matrix metalloproteinase-3 (MMP-3), adiponectin, and paraoxonase activity were measured by ELISA. Acylcarnitines and amino acids (AAs) were measured by mass spectrometry and reduced to a single factor using principal components analysis (PCA). Glycine was analyzed separately. The relationship between age and biomarkers was analyzed by linear regression with sex, race, and body mass index (BMI) as covariates. Age was positively correlated with TNF-, TNFR-I, TNFR-II, IL-6, IL-2, VCAM-1, D-Dimer, MMP-3, adiponectin, acylcarnitines, and AAs. Age was negative correlated with G-CSF, RANTES, and paraoxonase activity. BMI was significant for all biomarkers except IL-2, VCAM-1, RANTES, paraoxonase activity, and the AA factor. Excluding MMP-3, greater BMI was associated with potentially adverse changes in biomarker concentrations. Age-related changes in immune and metabolic biomarkers, known to be associated with poor outcomes in older adults, begin as early as the thirties.