Behavioural role of dopamine D1 receptors in the reserpine-treated mouse
Behavioural role of dopamine D1 receptors in the reserpine-treated mouse
复制标题
多巴胺 D1 受体在利血平治疗小鼠中的行为作用
DOI：
10.1016/0306-4522(87)90208-9
复制
发表时间：
1987
期刊：
影响因子：
3.3
通讯作者：
I. Kilpatrick
中科院分区：
文献类型：
--
作者：
B. Starr;M. Starr;I. Kilpatrick
研究了2,3,4,5-四氢-7,8-二羟基-1-苯基- 1h -3-苯氮平（SKF 38393）（激动剂）对利血平引起的低运动小鼠的运动行为的影响，在没有和存在n- n-丙基-n-苯乙基-p（3-羟基苯基）盐酸乙胺（RU 24213）、利尿苷（激动剂）或阿波啡（混合d1d2激动剂）的情况下。利血平（5mg /kg）刺激多巴胺d2受体3小时后，引起缓慢、沉重的行走和头朝下的嗅探。SKF 38393 （1.5-15 mg/kg）本身没有直接影响，但极大地增强了d2反应，使运动、饲养和梳理更加流畅。d1拮抗剂(R)-(+)-8-氯-2,3,4,5-四氢-3-甲基-5-苯基- 1h -3-benzazepin-7-ol (SCH 23390) （0.05 mg/kg）可抑制SKF 38393的促进作用，而d2对SCH 23390和d2拮抗剂甲氧氯普胺（0.5 mg/kg）均敏感。用利血平治疗24小时的小鼠对所有四种激动剂的运动刺激作用更加敏感。SKF 38393现在直接促进快速运动，饲养和梳理。相比之下，d2刺激的作用较弱，通常与d1拮抗剂具有拮抗作用（而不是协同作用）。两组激动剂现在只能被各自的拮抗剂减弱。利血平引起纹状体、嗅结节和大脑皮层中多巴胺、5-羟色胺和去甲肾上腺素浓度显著下降，代谢物水平相应升高。这些结果表明，d1和d2激动剂在利血平后3小时单独给药时对刺激行为相对无效，但在一起给药时相互作用，部分恢复运动、饲养和梳洗。这种相互作用在利血平作用后24小时不明显，此时d1和d2激动剂自身产生显著作用。
The effects of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF 38393) (D1agonist) on the motor behaviour of mice rendered hypokinetic with reserpine, were studied in the absence and presence of additional treatment withN-n-propyl-N-phenylethyl-p(3-hydroxyphenyl)ethylamine hydrochloride (RU 24213), lisuride (D2agonists) or apomorphine (mixed D1D2agonist). Three hours after reserpine (5 mg/kg) stimulating dopamine D2receptors evoked slow, ponderous walking and head-down sniffing. SKF 38393 (1.5–15 mg/kg) had no direct effect of its own, but greatly amplified the D2response, giving more fluent locomotion, rearing and grooming. The facilitatory action of SKF 38393 was inhibited by the D1antagonist (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (SCH 23390) (0.05 mg/kg), whereas D2-mediated responses were sensitive both to SCH 23390 and the D2antagonist metoclopramide (0.5 mg/kg). Mice treated with reserpine for 24 h became more sensitive to the motor stimulant actions of all four agonists. SKF 38393 now promoted rapid locomotion, rearing and grooming directly. The effects of D2stimulation were weak by comparison and often antagonistic (not synergistic) with those of the D1agonist. Both sets of agonists were now attenuated only by their respective antagonists. Reserpine caused pronounced falls in the concentrations of dopamine, 5-hydroxytryptamine and noradrenaline in the striatum, olfactory tubercle and cerebral cortex, with correspondingly elevated metabolite levels.These results indicate that D1and D2agonists at doses that are relatively ineffective at stimulating behaviour when given in isolation 3 h after reserpine, interact when given together to partially restore locomotion, rearing and grooming. This interaction is not apparent 24 h post-reserpine, a time at which D1and D2agonists produce significant effects of their own.
选择性 D2 多巴胺受体激动剂可预防由选择性 D1 拮抗剂 SCH 23390 引起的僵直症。
影响因子：
6.1
作者：
Meller,E;Kuga,S;Friedhoff,AJ;Goldstein,M
通讯作者：
Goldstein,M