Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice.
Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice.
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发表时间：
2010-06
影响因子：
0.6
通讯作者：
Uma S. Bhartiya;L. Joseph;Yogita S. Raut;B. Rao
中科院分区：
文献类型：
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作者：
Uma S. Bhartiya;L. Joseph;Yogita S. Raut;B. Rao
在小鼠中暴露于单次治疗剂量3.7MBq的131 I后，观察到唾液腺重量显著增加。补充抗氧化剂前，O。在131 I暴露前15天，圣所叶提取物、姜黄提取物和维生素E显示唾液腺重量显著降低。暴露24 h后，实验动物的唾液腺中未观察到重大组织病理学变化。骨髓嗜多染红细胞（PCE）和正染红细胞（NCE）的微核指数在所有实验组中保持不变。然而，PCE/NCE比值在骨髓中显着下降，在所有的131 I暴露的动物，无论抗氧化剂补充状态。在放射性碘暴露的小鼠中通过抗氧化剂预补充使唾液腺重量正常化提示抗氧化剂对唾液腺重量的可能改善作用，建议进一步详细研究高等动物唾液腺的功能方面。
Significant increase in the salivary gland weight was observed after exposure to single therapeutic dose of 3.7 MBq of 131I in mice. Pre-supplementation of antioxidants, O. sanctum leaf extract, turmeric extract and vitamin E for 15 days before 131I exposure demonstrated significant reduction in the salivary gland weight. No major histopathological changes were observed in the salivary gland of experimental animals at 24 h of exposure. Micronuclei index in the bone marrow of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained unchanged in all the experimental groups. However, PCE/NCE ratio in the bone marrow decreased significantly in all the 131I exposed animals irrespective of antioxidant supplementation status. The normalization of salivary gland weight by antioxidant pre-supplementation in radioiodine exposed mice is suggestive of the possible ameliorating effect of antioxidants on the salivary gland weight recommending further detailed studies regarding the functional aspect of the salivary gland in higher animals.