Increased anxiety of mice lacking the serotonin1A receptor
Increased anxiety of mice lacking the serotonin1A receptor
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DOI：
10.1073/pnas.95.18.10734
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发表时间：
1998-09-01
影响因子：
11.1
通讯作者：
Toth, M
中科院分区：
文献类型：
--
作者：
Parks, CL;Robinson, PS;Toth, M
脑5-羟色胺（5-HT）参与了许多生理过程和病理状态。这些作用由至少14种不同的5-HT受体介导。我们已经在小鼠中灭活了编码5-HT1A受体的基因，发现受体缺陷的动物更倾向于避免新的和可怕的环境，并逃避紧张的情况，这些行为与增加的焦虑和压力反应一致。基于5-HT 1A受体在5-HT系统的反馈调节中的作用，我们假设增加的多巴胺能神经传递是受体缺陷动物的焦虑样行为的原因。这一观点与早期的研究一致，表明5-HT系统的药理学激活在动物模型和人类中都是致焦虑的。
Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.