A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6
A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6
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DOI：
10.1039/b911145j
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Kim, Youngmi
中科院分区：
文献类型：
--
作者：
Kim, Tae-Il;Kang, Hyo Jin;Kim, Youngmi
通过对2-（2'-羟基苯基）苯并噻唑（HBT）发色团的简单磷酸化，设计了一种高选择性的蛋白酪氨酸磷酸酶（PTP）荧光探针：在选择性酶促水解时，发生激发态分子内质子转移（ESIPT），导致大的Stokes位移。
A highly selective fluorescent probe for a protein tyrosine phosphatase (PTP) was designed by a simple phosphorylation of the 2-(2'-hydroxyphenyl) benzothiazole (HBT) chromophore: upon selective enzymatic hydrolysis, an excited-state intramolecular proton transfer (ESIPT) occurs, resulting in a large Stokes shift.