Low-protein diet enhances adiponectin secretion in rats
Low-protein diet enhances adiponectin secretion in rats
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低蛋白饮食增强大鼠脂联素分泌
DOI：
10.1080/09168451.2019.1621153
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Minami Shiro
中科院分区：
文献类型：
--
作者：
Yagi Takashi;Toyoshima Yuka;Tokita Reiko;Taguchi Yusuke;Okamoto Yoshihisa;Takahashi Shin-Ichiro;Kato Hisanori;Minami Shiro
包括我们在内的先前研究表明，低蛋白饮食上调肝脏和肌肉中的胰岛素信号，并诱导大鼠脂肪肝。脂联素是一种胰岛素增敏脂肪细胞因子。因此，我们研究了低蛋白饮食对大鼠脂联素水平的影响。低蛋白饮食显著增加血清脂联素水平。然而，脂联素在白色脂肪组织（WAT）的mRNA和蛋白水平没有改变的低蛋白饮食。由于已知寡聚化对控制血清脂联素水平很重要，我们检查了WAT中脂联素寡聚体的数量，发现低蛋白饮食并没有改变它。尽管发生了这些事件，但在从低蛋白饮食喂养的大鼠WAT中分离的脂肪细胞中，其分泌量显着增加。这些结果表明，低蛋白饮食促进脂联素分泌，这不是由于脂联素的细胞内量增加和寡聚化。
Previous studies including ours have shown that a low-protein diet up-regulates insulin signaling in the liver and muscle and induces fatty liver in rats. Adiponectin is known as an insulin-sensitizing adipocytokine. We, therefore, examined the effect of a low-protein diet on the adiponectin levels in rats. The low-protein diet significantly increased serum adiponectin level. However, mRNA and protein levels of adiponectin in white adipose tissue (WAT) were not changed by the low-protein diet. Since it is known that oligomerization is important to control serum adiponectin level, we examined the population of adiponectin oligomeric forms in WAT and found that low-protein diet did not change it. Despite these events, the amount of its secretion was significantly increased in the adipocytes isolated from WAT of low-protein diet-fed rats. These results indicate that a low-protein diet enhances adiponectin secretion, which is not due to the increased intracellular amount and oligomerization of adiponectin.