Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures
Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures
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DOI：
10.1126/science.1185547
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发表时间：
2010-05-21
期刊：
影响因子：
56.9
通讯作者：
Ropponen, Jarmo
中科院分区：
文献类型：
--
作者：
Percec, Virgil;Wilson, Daniela A.;Ropponen, Jarmo
从天然和合成的两亲物中获得的自组装纳米结构用作生物膜的模拟物，并且能够递送药物、蛋白质、基因和成像剂。然而，这些功能所要求的精确分子排列很难实现。两亲性Janus树枝状聚合物，通过定制的亲水性和疏水性分支段的轻松耦合制备的库，已经通过低温透射电子显微镜筛选，揭示了丰富的调色板的形态在水中，包括囊泡，表示dendrimersomes，cubosomes，磁盘，管状囊泡，和螺旋带。树枝状体将可从聚合物囊泡获得的稳定性和机械强度与稳定化磷脂脂质体的生物功能结合，加上尺寸的上级均匀性、易于形成和化学官能化。这种模块化合成策略提供了对分子结构和自组装结构进行系统调整的途径。
Self-assembled nanostructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and enable the delivery of drugs, proteins, genes, and imaging agents. Yet the precise molecular arrangements demanded by these functions are difficult to achieve. Libraries of amphiphilic Janus dendrimers, prepared by facile coupling of tailored hydrophilic and hydrophobic branched segments, have been screened by cryogenic transmission electron microscopy, revealing a rich palette of morphologies in water, including vesicles, denoted dendrimersomes, cubosomes, disks, tubular vesicles, and helical ribbons. Dendrimersomes marry the stability and mechanical strength obtainable from polymersomes with the biological function of stabilized phospholipid liposomes, plus superior uniformity of size, ease of formation, and chemical functionalization. This modular synthesis strategy provides access to systematic tuning of molecular structure and of self-assembled architecture.