Near-infrared reflectance imaging of neovascular age-related macular degeneration.
Near-infrared reflectance imaging of neovascular age-related macular degeneration.
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DOI：
10.1007/s00417-009-1148-9
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Klevering BJ
中科院分区：
文献类型：
--
作者：
Theelen T;Berendschot TT;Hoyng CB;Boon CJ;Klevering BJ
与眼底荧光素血管造影（FFA）相比，通过近红外眼底反射（NIR）评估各种类型的新生血管性黄斑变性（AMD），并测试近红外评估脉络膜新生血管（CNV）引起的渗漏。采用共聚焦扫描激光检眼镜（Heidelberg视网膜血管造影2）检查33例新生血管性AMD患者（例）和20例年龄匹配的非渗出性AMD患者（对照组）。将新生血管性AMD的近红外图像与相应的FFA和年龄匹配的对照组进行定性比较。在FFA和NIR上手工分割CNV膜和渗出区域并定量分析。在所有病例中，5眼为典型CNV， 6眼为最小典型病变，15眼为隐匿性CNV， 7眼为视网膜血管瘤性增生（RAP）。所有病例在近红外光谱上均发现暗晕，与FFA渗漏高度对应（r 2 = 0.93; p < 0005）。在经典CNV和最小经典CNV中，FFA上病灶的经典部分与近红外上明亮反射环包围的暗核有很强的相关性（r 2 = 0.88; p < 0.0005）。最小典型CNV和隐匿性CNV病变的FFA隐匿部分表现为边界不清、锯齿状的近红外区升高。RAP的特征是位于视网膜内新生血管复合体的斑点状近红外。新生血管性AMD的近红外成像显示CNV类型的特征性改变。这些变化可能反映了病变的组织学差异。泄漏引起近红外局部变暗，可能是由于流体积聚和亚细胞结构改变引起的光散射和吸收增加。
To evaluate various types of neovascular age-related macular degeneration (AMD) by near-infrared fundus reflectance (NIR) as compared to fundus fluorescein angiography (FFA) and to test NIR for assessment of leakage due to choroidal neovascularization (CNV). Thirty-three patients with neovascular AMD (cases) and 20 age-matched patients with non-exudative AMD and healthy subjects (controls) were examined with a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2). NIR images of neovascular AMD were qualitatively compared to the corresponding FFA and to age-matched controls. CNV membranes and exudation areas were manually segmented on FFA and NIR and analyzed quantitatively. Of all cases included, five eyes had classic CNV, six had minimal classic lesions, 15 occult CNV’s and seven eyes had retinal angiomatous proliferation (RAP). A dark halo on NIR was found in all cases and showed high correspondence to leakage on FFA (r 2 = 0.93; p < 0,0005). In classic CNV and minimal classic CNV, the classic part of the lesion on FFA revealed strong correlation to a dark core surrounded by a bright reflecting ring on NIR (r 2 = 0.88; p < 0.0005). Occult parts on FFA of minimal classic CNV and occult CNV lesions appeared as poorly demarcated, jagged areas of increased NIR. RAP was characterized by speckled NIR located at the intraretinal neovascular complex. NIR imaging in neovascular AMD revealed characteristic alterations depending on the type of CNV. These changes may reflect histological differences of the lesions. Leakage caused local darkening of NIR, presumably originating from increased light-scattering and absorbance by fluid accumulation and sub-cellular structure alterations.
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影响因子：
17.8
作者：
Schmidt-Erfurth, Ursula M.;Pruente, Christian
通讯作者：
Pruente, Christian
DOI：
10.1097/00006982-200212000-00001
发表时间：
2002-12-01
影响因子：
3.3
作者：
Kaiser, RS;Berger, JW;Margherio, RM
通讯作者：
Margherio, RM
影响因子：
13.7
作者：
Holz, FG;Jorzik, J;Unnebrink, K
通讯作者：
Unnebrink, K
影响因子：
4.2
作者：
Coscas, Florence;Coscas, Gabriel;Soubrane, Gisele
通讯作者：
Soubrane, Gisele
影响因子：
13.7
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.