Safflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in Aβ1-42-induced AD Model Rats
Safflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in Aβ1-42-induced AD Model Rats
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DOI：
10.1007/s11064-020-03051-w
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发表时间：
2020-05-14
影响因子：
4.4
通讯作者：
Hu, Yanli
中科院分区：
文献类型：
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作者：
Hou, Jiawei;Wang, Chunhui;Hu, Yanli
红花黄色素（SY）是红花的主要有效成分，其中含量最高的单一活性成分是羟基红花黄色素A（HSYA）。SY和HSYA已被证明在几种AD模型中具有神经保护作用。本研究旨在阐明SY和HSYA对A β（1 - 42）诱导的AD模型大鼠学习记忆能力的影响是否与增强脑组织突触结构可塑性和改善谷氨酸循环障碍有关。我们使用双侧海马内注射A β（1 - 42）的大鼠作为AD模型。SY和HSYA能增强A β（1 - 42）诱导的AD模型大鼠的学习记忆能力，减少A β沉积，减轻树突棘结构损伤和突触相关蛋白丢失，改善谷氨酸循环障碍。结果表明，SY和HSYA通过改善A β（1 - 42）诱导的AD模型大鼠谷氨酸循环障碍，改善突触结构可塑性。
Safflower yellow (SY) is the main effective component of Carthamus tinctorius L., and Hydroxysafflor yellow A (HSYA) is the single active component with the highest content in SY. SY and HSYA have been shown to have neuroprotective effects in several AD models. In this study, we aimed to clarify whether the effects of SY and HSYA on the learning and memory abilities of A beta(1-42)-induced AD model rats are related to the enhancement of synaptic structural plasticity in brain tissues and the amelioration of disorder of glutamate circulation. We used rats injected with A beta(1-42) into the bilateral hippocampus as a model of AD. After treatment with SY and HSYA, the learning and memory abilities of the A beta(1-42)-induced AD model rats were enhanced, A beta deposition in the AD model rats was decreased, structural damage to dendritic spines and the loss of synaptic-associated proteins were alleviated, and the disorder of glutamate circulation was ameliorated. The results indicated that SY and HSYA improve synaptic structural plasticity by ameliorating the disorder of glutamate circulation in A beta(1-42)-induced AD model rats.