CONTINUOUS LINES OF BASOPHIL-MAST CELLS DERIVED FROM NORMAL MOUSE BONE-MARROW
CONTINUOUS LINES OF BASOPHIL-MAST CELLS DERIVED FROM NORMAL MOUSE BONE-MARROW
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DOI：
10.1126/science.7209531
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
AARONSON, SA
中科院分区：
文献类型：
--
作者：
NAGAO, K;YOKORO, K;AARONSON, SA
从不同品系小鼠的正常骨髓中建立非贴壁组织培养细胞系。这些细胞系具有嗜碱粒细胞/肥大细胞的形态和组织化学标记，并含有异染细胞的定向干细胞。它们来源于正常骨髓，尽管长期培养，但缺乏致瘤性，这使得这些细胞系对于研究过敏反应和炎症的机制以及涉及这一造血细胞亚群的分化途径具有潜在的重要意义。
Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed stem cells for metachromatic cells. Their derivation from normal marrow and their lack of tumorigenicity despite long-term culture makes these cell lines potentially important for studies of the mechanisms of allergic reactions and inflammation and the differentiation pathways involving this subset of hematopoietic cells.