The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans
The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans
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DOI：
10.1038/s41551-021-00739-4
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发表时间：
2021-06-21
影响因子：
28.1
通讯作者：
Langer, Robert
中科院分区：
文献类型：
--
作者：
Doloff, Joshua C.;Veiseh, Omid;Langer, Robert
硅胶广泛用于慢性植入物，通常被认为是安全的。然而，纹理乳房植入物与免疫相关的并发症有关，包括恶性肿瘤。在这里，我们通过对小型化或临床批准的不同表面形貌(平均粗糙度，0-90微米)的乳房植入物分别放置在小鼠或兔的乳脂垫上长达一年的异物反应和包膜纤维化的检测，我们发现表面形貌介导了对植入物的免疫反应。我们还表明，在翻修手术中收集的人类乳房植入物周围的表面也会不同地改变个人对植入物的免疫反应。此外，平均粗糙度为4微米的微型植入物可以在很大程度上抑制异物反应和纤维化(但在T细胞缺陷小鼠中不是)，并且这些植入物周围的组织显示出更高水平的免疫抑制FOXP3(+)调节性T细胞。我们的研究结果表明，在所研究的地形中，平均粗糙度为4微米的植入物引起的炎症和异物反应最少，乳房假体的表面形貌介导了对其的免疫反应，平均粗糙度为4微米的植入物在很大程度上抑制了异物反应和纤维化。
Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 mu m) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants. We also show that the surface surrounding human breast implants collected during revision surgeries also differentially alters the individual's immune responses to the implant. Moreover, miniaturized implants with an average roughness of 4 mu m can largely suppress the foreign body response and fibrosis (but not in T-cell-deficient mice), and that tissue surrounding these implants displayed higher levels of immunosuppressive FOXP3(+) regulatory T cells. Our findings suggest that, amongst the topographies investigated, implants with an average roughness of 4 mu m provoke the least amount of inflammation and foreign body response.The surface topography of breast implants mediates the immune responses to them, and implants with an average roughness of 4 mu m largely suppress foreign body response and fibrosis.