A PC-based software test for measuring alcohol and drug effects in human subjects.
A PC-based software test for measuring alcohol and drug effects in human subjects.
复制标题
一种基于 PC 的软件测试，用于测量酒精和药物对人类受试者的影响。
DOI：
10.1111/j.1530-0277.1996.tb01703.x
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Spruill,SE
中科院分区：
文献类型：
--
作者：
Mills,KC;Parkman,KM;Spruill,SE
开发了一种新的基于软件的视觉搜索和认知表现的分散注意力测试，并在一项酒精剂量反应研究中对24名21-62岁的人类受试者进行了评估。该测试使用无语言、彩色、图形显示来表示驾驶的视觉空间需求。与以往基于硬件的测试相比，认知需求增加了，测试所需的运动技能包括最小的眼动和手眼协调。通过使用安慰剂和两种酒精剂量(低剂量（0.48 g/kg/LBM）和中剂量（0.72 g/kg/LBM），用拉丁方设计评估试验的重复表现。7名女性和17名男性的数据显示，呼吸酒精水平的中度上升和下降（平均峰值BrALs = 0.045 g/dl和0.079 g/dl）导致损伤显著下降和上升。与以前的测试相比，没有受试者报告眼睛疲劳或精神运动性疲劳。讨论了在基础研究和应用研究中使用的高灵敏度/方差，以及工作场所适合度测试。在现成的个人电脑上运行的基于软件的测试最明显的优势是，它可以广泛分发给研究人员，作为比较各种酒精和药物影响的共同参考。
A new software‐based visual search and divided‐attention test of cognitive performance was developed and evaluated in an alcohol dose‐response study with 24 human subjects aged 21–62 years. The test used language‐free, color, graphic displays to represent the visuospatial demands of driving. Cognitive demands were increased over previous hardware‐based tests, and the motor skills required for the test involved minimal eye movements and eye‐hand coordination. Repeated performance on the test was evaluated with a latin‐square design by using a placebo and two alcohol doses, low (0.48 g/kg/LBM) and moderate (0.72 g/kg/LBM). The data on 7 females and 17 males yielded significant falling and rising impairment effects coincident with moderate rising and falling breath alcohol levels (mean peak BrALs = 0.045 g/dl and 0.079 g/dl). None of the subjects reported eye‐strain or psychomotor fatigue as compared with previous tests. The high sensitivity/variance relative to use in basic and applied research, and worksite fitness‐for‐duty testing, was discussed. The most distinct advantage of a software‐based test that operates on readily available PCs is that it can be widely distributed to researchers with a common reference to compare a variety of alcohol and drug effects.