Cobalt-catalyzed cyclization of benzamides with alkynes: a facile route to isoquinolones with hydrogen evolution
Cobalt-catalyzed cyclization of benzamides with alkynes: a facile route to isoquinolones with hydrogen evolution
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DOI：
10.1039/c8ob01924j
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发表时间：
2018-10-07
影响因子：
3.2
通讯作者：
Jeganmohan, Masilamani
中科院分区：
文献类型：
--
作者：
Manoharan, Ramasamy;Jeganmohan, Masilamani
在空气气氛下，Co（OAc）（2）中心点4 H（2）O和特戊酸存在下，8-氨基喹啉配体辅助苯甲酰胺与炔的反应，以良好至优异的产率得到异喹诺酮衍生物.在该反应中，活性Co（III）物质通过Co（I）物质与新戊酸在空气气氛下反应并放出氢气而再生。竞争实验、氘标记实验、自由基清除实验和动力学研究均支持该机制。
The reaction of benzamides with alkynes assisted by an 8-aminoquinoline ligand in the presence of Co(OAc)(2)center dot 4H(2)O and pivalic acid under an air atmosphere provided isoquinolone derivatives in good to excellent yields. In this reaction, the active Co(III) species is regenerated by the reaction of Co(I) species with pivalic acid under an air atmosphere with hydrogen evolution. The proposed mechanism was supported by competition experiments, deuterium labelling studies, radical scavenger experiments and kinetic studies.