A CONTINUOUS, IMPLANTABLE LACTATE SENSOR
A CONTINUOUS, IMPLANTABLE LACTATE SENSOR
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DOI：
10.1021/ac00105a010
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发表时间：
1995-05-01
影响因子：
7.4
通讯作者：
GOUGH, DA
中科院分区：
文献类型：
--
作者：
BAKER, DA;GOUGH, DA
一种用于连续监测血液或组织中乳酸的植入式传感器已经被制造出来。该传感器包括基于固定化 L-乳酸氧化酶的乳酸电极，该电极与恒电位氧电极和氧参比电极耦合以考虑局部氧。这种设计使得响应基本上与氧气浓度无关。体外表征表明，该传感器可以在较宽的浓度范围内对乳酸做出特异性响应。该反应在体温下连续体外操作中稳定超过1周。作为犬右心房的急性植入物，该传感器可以连续记录乳酸，这与传统的离散血乳酸测定非常一致。
An implantable sensor for continuous monitoring of lactate in the bloodstream or tissues has been made. The sensor includes a lactate electrode based on immobilized L-lactate oxidase coupled to a potentiostatic oxygen electrode and an oxygen reference electrode to account for local oxygen. This design renders the response essentially independent of oxygen concentration. In vitro characterization demonstrated that the sensor can respond specifically to lactate over a broad concentration range. This response is stable for more than 1 week curing continuous in vitro operation at body temperature. As an acute implant in the canine right atrium, the sensor produced a continuous recording of lactate that was in good agreement with conventional, discrete blood lactate assays.