The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
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DOI：
10.1111/acel.12389
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发表时间：
2015-12
期刊：
影响因子：
7.8
通讯作者：
Hirose N
中科院分区：
文献类型：
--
作者：
Fuku N;Pareja-Galeano H;Zempo H;Alis R;Arai Y;Lucia A;Hirose N
线粒体衍生肽 (MDP) 由线粒体 DNA (mtDNA) 中的功能性短开放阅读框编码。其中包括护脑素和最近发现的 12S rRNA-c (MOTS-c) 线粒体开放阅读框。尽管还需要更多的研究，但我们认为，编码 mtDNA 的 MOTS-c 中的 m.1382A>C 多态性（东北亚人群特有）可能是解释日本人长寿的推定生物学机制之一。
Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS‐c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.